Jiao Rong, Lin Xia, Wang Jingchao, Zhu Chunyan, Hu Jiang, Gao Huali, Zhang Kun
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, China.
Department of Orthopedic Surgery, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
J Pharm Anal. 2024 Dec;14(12):100925. doi: 10.1016/j.jpha.2023.12.015. Epub 2023 Dec 21.
Cartilage is solid connective tissue that recovers slowly from injury, and pain and dysfunction from cartilage damage affect many people. The treatment of cartilage injury is clinically challenging and there is no optimal solution, which is a hot research topic at present. With the rapid development of 3D printing technology in recent years, 3D bioprinting can better mimic the complex microstructure of cartilage tissue and thus enabling the anatomy and functional regeneration of damaged cartilage. This article reviews the methods of 3D printing used to mimic cartilage structures, the selection of cells and biological factors, and the development of bioinks and advances in scaffold structures, with an emphasis on how 3D printing structure provides bioactive cargos in each stage to enhance the effect. Finally, clinical applications and future development of simulated cartilage printing are introduced, which are expected to provide new insights into this field and guide other researchers who are engaged in cartilage repair.
软骨是一种固体结缔组织，损伤后恢复缓慢，软骨损伤引起的疼痛和功能障碍影响着许多人。软骨损伤的治疗在临床上具有挑战性，目前尚无最佳解决方案，这是当前的一个热门研究课题。近年来，随着3D打印技术的快速发展，3D生物打印能够更好地模拟软骨组织的复杂微观结构，从而实现受损软骨的解剖学和功能再生。本文综述了用于模拟软骨结构的3D打印方法、细胞和生物因子的选择、生物墨水的发展以及支架结构的进展，重点介绍了3D打印结构在各个阶段如何提供生物活性物质以增强效果。最后，介绍了模拟软骨打印的临床应用和未来发展，期望为该领域提供新的见解，并指导其他从事软骨修复的研究人员。
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