National School of Development, Peking University, No. 5 Yiheyuan Road, Haidian, Beijing, 100871, China.
School of Social Work, The University of Iowa, 225B North Hall, Iowa, IA, 52242, USA.
Aging Clin Exp Res. 2021 Nov;33(11):3073-3080. doi: 10.1007/s40520-021-01827-w. Epub 2021 Mar 20.
To investigate the longitudinal association of metabolic syndrome (MetS) and its components with disability outcomes.
A total of 5875 participants aged 60 and above completed the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS). MetS at baseline was measured by the National Cholesterol Education Program Adult Treatment Panel III criteria. Logistic regressions were conducted to analyze the associations between baseline MetS and incident disability, measured as the onset of limitations regarding instrumental activities of daily living (IADL) and activities of daily living (ADL) 4 years later. Linear regression was adopted to analyze the longitudinal impact of baseline MetS on the number of IADL and ADL limitations in 2015. A comprehensive list of baseline covariates was adjusted in all regression analyses.
Baseline MetS was related to increased odds of incident IADL disability (OR = 1.28, 95% CI 1.05-1.55) and incident ADL disability (OR = 1.27, 95% CI 1.05-1.53) among disability-free participants at baseline. Baseline MetS was also associated with an increase in the number of IADL (beta = 0.15, 95% CI 0.07-0.23) and ADL limitations (beta = 0.10, 95% CI 0.01-0.18), while adjusting for baseline functional performance. Significant MetS component predictors of disability outcomes include abdominal obesity, high blood pressure, and a low level of high-density lipoprotein cholesterol.
Our findings suggest an increased risk of incident disability and deteriorated functional performance over 4 years, associated with the presence of MetS and its components.
探讨代谢综合征（MetS）及其各组分与残疾结局的纵向关联。
共有 5875 名年龄在 60 岁及以上的参与者完成了中国健康与退休纵向研究（CHARLS）的 2011 年和 2015 年两轮调查。基线时采用美国国家胆固醇教育计划成人治疗专家组 III 标准来测量 MetS。采用逻辑回归分析基线 MetS 与 4 年后发生残疾（定义为工具性日常生活活动能力（IADL）和日常生活活动能力（ADL）受限）的关联。采用线性回归分析基线 MetS 对 2015 年 IADL 和 ADL 受限数量的纵向影响。在所有回归分析中均调整了基线时全面的协变量列表。
在基线时无残疾的参与者中，基线 MetS 与 IADL 残疾（OR=1.28，95%CI 1.05-1.55）和 ADL 残疾（OR=1.27，95%CI 1.05-1.53）的发生几率增加相关。基线 MetS 还与 IADL（beta=0.15，95%CI 0.07-0.23）和 ADL 受限数量（beta=0.10，95%CI 0.01-0.18）的增加相关，同时调整了基线时的功能表现。残疾结局的显著 MetS 组分预测因子包括腹型肥胖、高血压和低水平高密度脂蛋白胆固醇。
我们的研究结果表明，存在 MetS 及其各组分与残疾发生风险增加和 4 年内功能表现恶化相关。
