Department of Biology, Faculty of Sciences, University of Tehran, Iran.
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran; Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
Biomed Pharmacother. 2021 Jun;138:111492. doi: 10.1016/j.biopha.2021.111492. Epub 2021 Mar 17.
Thymoquinone (TQ, 2-methyl-5-isopropyl-1, 4-benzoquinone), a monoterpene molecule present in Nigella sativa L., has an anti-inflammatory, anti-oxidant, and anti-apoptotic properties in several disorders such as asthma, hypertension, diabetes, inflammation, bronchitis, headache, eczema, fever, dizziness and influenza. TQ exerts its anti-inflammatory and anti-oxidant effects via several molecular pathways, including the release of cytokines, and activation of cyclooxygenase-2 (COX2), nuclear factor erythroid 2-related factor 2 (Nrf2), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), nuclear factor kappa-light-chain-enhancer of activated B (NF-Κβ). In this review, recent reports on the anti-inflammatory efficacy of TQ in heart disorders, respiratory diseases, neuroinflammation, diabetes and arthritis are summarized. We suggest that further investigation is necessary to better characterize the efficacy of TQ as a therapeutic agent.
百里醌（TQ，2-甲基-5-异丙基-1,4-苯醌）是存在于黑种草中的单萜分子，具有抗炎、抗氧化和抗细胞凋亡的特性，可用于治疗哮喘、高血压、糖尿病、炎症、支气管炎、头痛、湿疹、发烧、头晕和流感等多种疾病。TQ 通过多种分子途径发挥其抗炎和抗氧化作用，包括细胞因子的释放以及环氧化酶-2（COX2）、红细胞生成素相关因子 2（Nrf2）、磷脂酰肌醇 3-激酶/蛋白激酶 B（PI3K/AKT）、核因子 kappa-轻链增强子的激活 B（NF-Κβ）的激活。在这篇综述中，总结了 TQ 在心脏疾病、呼吸疾病、神经炎症、糖尿病和关节炎中的抗炎功效的最新报道。我们建议有必要进一步研究以更好地描述 TQ 作为治疗剂的功效。
