非编码 RNA 与 Twist1 信号通路的相互作用导致了人类疾病的发生。
The interplay between non-coding RNAs and Twist1 signaling contribute to human disorders.
机构信息
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Biomed Pharmacother. 2021 Mar;135:111220. doi: 10.1016/j.biopha.2021.111220. Epub 2021 Feb 1.
Twist-related protein 1 (Twist1) is a basic helix-loop-helix (bHLH) transcription factor (TF) being coded by the TWIST1 gene. This TF has a fundamental effect on the normal development and in the pathogenesis of various diseases especially cancer. Twist1 has interactions with some long non-coding RNAs and miRNAs. The interactions between this TF and various miRNAs such as miR-16, miR-26b-5p, miR-1271, miR-539, miR-214, miR-200b/c, miR-335, miR-10b, and miR-381 are implicated in the carcinogenic processes. TP73-AS1, LINC01638, ATB, NONHSAT101069, CASC15, H19, PVT1, LINC00339, LINC01385, TANAR, SNHG5, DANCR, CHRF, and TUG1 are among long non-coding RNAs which interact with Twist1 and participate in the carcinogenesis. This review aims at depicting the interaction between these non-coding transcripts and Twist1 and the consequence of these interactions in human neoplasms.
Twist 相关蛋白 1（Twist1）是一种碱性螺旋-环-螺旋（bHLH）转录因子（TF），由 TWIST1 基因编码。这种 TF 对正常发育和各种疾病特别是癌症的发病机制有重要影响。Twist1 与一些长非编码 RNA 和 miRNA 相互作用。该 TF 与各种 miRNA 之间的相互作用，如 miR-16、miR-26b-5p、miR-1271、miR-539、miR-214、miR-200b/c、miR-335、miR-10b 和 miR-381，与致癌过程有关。TP73-AS1、LINC01638、ATB、NONHSAT101069、CASC15、H19、PVT1、LINC00339、LINC01385、TANAR、SNHG5、DANCR、CHRF 和 TUG1 是与 Twist1 相互作用并参与致癌作用的长非编码 RNA 之一。本综述旨在描述这些非编码转录物与 Twist1 之间的相互作用以及这些相互作用在人类肿瘤中的后果。
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