Niazi Vahid, Ghafouri-Fard Soudeh
Stem Cell Research Center, Golestan University of Medical Science, Gorgan, Iran.
School of Advanced Technologies in Medicine, Golestan University of Medical Science, Gorgan, Iran.
Histochem Cell Biol. 2024 Dec 23;163(1):19. doi: 10.1007/s00418-024-02348-z.
Hematopoietic stem cells (HSCs) reside in a milieu that supports their functions, differentiation, and survival. This niche consists of several types of cells, including mesenchymal stem/stromal cells, endothelial cells, osteoblasts, megakaryocytes, macrophages, adipocytes, lymphoid cells, and nerve fibers. The interactions between these cells and HSCs have a role in HSC fate. Several studies have focused on identification of the biological and cellular mechanisms contributing to the establishment of this niche. However, the exact mechanisms of the interaction between HSCs and the bone marrow niche have not been elucidated yet. Unraveling these mechanisms would help in the design of effective methods for maintenance and multiplication of HSCs in clinical settings, in addition to establishment of novel therapies for hematopoietic diseases. The current review summarizes the effects of the niche cells on HSC function and underlying mechanisms of interplay between HSCs and their niche.
造血干细胞（HSCs）存在于支持其功能、分化和存活的微环境中。这个生态位由几种类型的细胞组成，包括间充质干/基质细胞、内皮细胞、成骨细胞、巨核细胞、巨噬细胞、脂肪细胞、淋巴细胞和神经纤维。这些细胞与造血干细胞之间的相互作用对造血干细胞的命运具有重要作用。多项研究聚焦于确定促成这一生态位形成的生物学和细胞机制。然而，造血干细胞与骨髓生态位之间相互作用的确切机制尚未阐明。阐明这些机制将有助于设计在临床环境中维持和扩增造血干细胞的有效方法，此外还有助于建立针对造血系统疾病的新疗法。本综述总结了生态位细胞对造血干细胞功能的影响以及造血干细胞与其生态位之间相互作用的潜在机制。
