Department of Family and Community Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Obstetrics and Gynaecology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Int J Clin Pract. 2021 Jun;75(6):e14156. doi: 10.1111/ijcp.14156. Epub 2021 Mar 26.
This study aimed to determine rubella virus infectivity and immune status in pregnant females who visited the family medicine and obstetrics clinics at a large hospital in Saudi Arabia, and to identify the possible predictors of rubella susceptibility.
This registered-based, cross-sectional study included pregnant, aged between 18 and 50 years old, who presented for the first antenatal visit between 2017 and 2020. Data on sociodemographic, antenatal characteristics and serological results were collected. Chi-Squared or Fisher's Exact test and t tests were used for bivariate analysis followed by the multivariable logistic regression model.
A total of 4328 pregnant were included in the study. Seroprevalence of rubella immunity was 76.41%. Positive rubella IgM antibody was identified in 1.21% of those who performed the test (17/1409). Odds of susceptibility were decreased with an increase in age (OR = 0.96, 95% CI = 0.95-0.97) and in non-Saudis' (OR = 0.44, 95% CI = 0.36-0.54).
Approximately 24% of pregnant were susceptible to rubella virus infections in this study. Screening females of child-bearing age and reimmunisation of susceptible cases before pregnancy are suggested. Further studies to investigate the impact of applying this policy in premarital screening are recommended.
本研究旨在确定在沙特阿拉伯一家大医院的家庭医学和妇产科诊所就诊的孕妇的风疹病毒感染和免疫状况，并确定风疹易感性的可能预测因素。
本基于注册的横断面研究纳入了 2017 年至 2020 年间首次进行产前检查的年龄在 18 至 50 岁之间的孕妇。收集了社会人口统计学、产前特征和血清学结果数据。使用卡方检验或 Fisher 精确检验和 t 检验进行单变量分析，然后进行多变量逻辑回归模型分析。
本研究共纳入 4328 名孕妇。风疹免疫力的血清阳性率为 76.41%。对 1409 名接受检测的孕妇中的 17 人（1.21%）检测到风疹 IgM 抗体阳性。年龄增加（OR=0.96，95%CI=0.95-0.97）和非沙特人（OR=0.44，95%CI=0.36-0.54）使易感性的可能性降低。
在本研究中，约 24%的孕妇易感染风疹病毒。建议对育龄妇女进行筛查，并对易感病例在怀孕前进行再免疫。建议进一步研究在婚前检查中应用这一政策的影响。
