Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Obes Res Clin Pract. 2021 May-Jun;15(3):256-261. doi: 10.1016/j.orcp.2021.03.004. Epub 2021 Mar 18.
Hypovitaminosis D which is a frequent problem in overweight and obese individuals, seems to interfere with cells responsible for control of glycemic status. Therefore, the current research intended to study the impact of supplementation with vitamin D on insulin homeostasis among healthy obese and overweight individuals.
The current study was conducted among obese or overweight individuals who had hypovitaminosis D. After separation of participants into two groups, one group received vitamin D pearls (50,000 IU/weekly) for eight weeks, whereas another group received a placebo over the same period. Next, the level of vitamin D, fasting blood sugar (FBS), fasting insulin, Homeostasis Model Assessment 2 for Insulin Resistance (HOMA2-IR), Function of β-cell (HOMA2-β), and Insulin Sensitivity (HOMA2-S) and lipid profile of participants were evaluated.
Overall, 67.2% of the participants were female. No considerable difference was observed concerning biochemical parameters among the study groups at baseline. After eight weeks, the mean (SD) level of vitamin D was significantly lower in the placebo group than those in the vitamin D group. (38.6 ± 8.1 vs. 14.9 ± 6.4; P < 0.001). The patients who received vitamin D had significant lower levels of FBS (P < 0.001), fasting insulin (P < 0.001), HOMA2-IR (P < 0.001), and HOMA2-β (P = 0.03), than the placebo group. The HOMA2-S was significantly enhanced in vitamin D group, while it reduced in another group (P < 0.001). However, no considerable decrease was found in triglyceride, cholesterol, high-density lipoprotein or low-density lipoprotein.
Supplementation with vitamin D improved sensitivity to insulin and pancreatic function of β cells of healthy overweight and obese adults.
超重和肥胖人群中普遍存在的维生素 D 缺乏症似乎会干扰负责控制血糖状态的细胞。因此，目前的研究旨在研究补充维生素 D 对健康超重和肥胖个体胰岛素稳态的影响。
本研究在维生素 D 缺乏的肥胖或超重个体中进行。将参与者分为两组后，一组接受维生素 D 丸（每周 50,000IU）治疗 8 周，另一组在同一时期接受安慰剂治疗。然后评估参与者的维生素 D 水平、空腹血糖（FBS）、空腹胰岛素、胰岛素抵抗的稳态模型评估 2（HOMA2-IR）、β 细胞功能（HOMA2-β）和胰岛素敏感性（HOMA2-S）以及血脂谱。
总体而言，67.2%的参与者为女性。在基线时，研究组之间的生化参数没有明显差异。八周后，安慰剂组的平均（SD）维生素 D 水平明显低于维生素 D 组（38.6±8.1 对 14.9±6.4；P<0.001）。接受维生素 D 治疗的患者 FBS（P<0.001）、空腹胰岛素（P<0.001）、HOMA2-IR（P<0.001）和 HOMA2-β（P=0.03）水平显著降低，而安慰剂组则降低。HOMA2-S 在维生素 D 组显著升高，而在另一组则降低（P<0.001）。然而，甘油三酯、胆固醇、高密度脂蛋白或低密度脂蛋白没有明显下降。
补充维生素 D 可改善健康超重和肥胖成年人对胰岛素的敏感性和β 细胞功能。
