School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD, 4558, Australia.
Qual Life Res. 2021 Aug;30(8):2265-2273. doi: 10.1007/s11136-021-02821-5. Epub 2021 Mar 21.
We aimed to explore the relationship between characteristics of the sarcopenic phenotype and health-related quality of life (HRQoL) in community-dwelling overweight and obese older adults with and without type 2 diabetes mellitus (T2DM).
Appendicular lean mass (ALM), corrected for height (ALM/m) was assessed by dual-energy X-ray absorptiometry. Muscle strength was assessed using handgrip strength (HGS), and lower extremity physical function was assessed using the Short Performance Physical Battery (SPPB) and gait speed. HRQoL was determined using the short-form 36 (SF-36) survey. Multiple regression analysis was used to examine the association between characteristics of the sarcopenic phenotype and domains of HRQoL.
A total of n = 152 community-dwelling older adults were included (T2DM cohort: n = 87, 71.2 ± 8.2 years, BMI: 29.5 ± 5.9 kg/m; Obese cohort: n = 65, 68.7 ± 5.6 years, BMI: 33.7 ± 4.9 kg/m). After adjusting for potential confounders, gait speed and SPPB were positively associated with the physical function subscale of HRQoL (Gait speed: ß = 0.658; P < 0.001; SPPB: ß = 0.478; P < 0.001). This relationship was also maintained for gait speed when assessed independently by cohort (T2DM cohort: ß = 0.637; P < 0.001; Obese cohort: ß = 0.507; P = 0.003).
Our results further contribute to the literature suggesting that lower body extremity function is associated with the physical function subscale of HRQoL. However, larger longitudinal data are required to assess whether lower body extremity function is independently associated with HRQoL, which includes the potential impact of nutrition and physical activity status.
我们旨在探讨社区居住的超重和肥胖老年 2 型糖尿病（T2DM）患者与非 T2DM 患者中，与肌少症表型特征相关的健康相关生活质量（HRQoL）与身体机能的关系。
通过双能 X 射线吸收法评估四肢瘦组织质量（ALM），并对其进行身高校正（ALM/m）。使用握力（HGS）评估肌肉力量，使用简短体能测试（SPPB）和步态速度评估下肢身体机能。使用简短 36 项健康调查（SF-36）来确定 HRQoL。采用多元回归分析来检验肌少症表型特征与 HRQoL 各领域之间的关系。
共纳入 152 名社区居住的老年人（T2DM 队列：n=87，71.2±8.2 岁，BMI：29.5±5.9 kg/m2；肥胖队列：n=65，68.7±5.6 岁，BMI：33.7±4.9 kg/m2）。在调整了潜在混杂因素后，步态速度和 SPPB 与 HRQoL 的身体机能亚量表呈正相关（步态速度：β=0.658；P<0.001；SPPB：β=0.478；P<0.001）。当分别按队列评估时，这种关系仍然存在于步态速度中（T2DM 队列：β=0.637；P<0.001；肥胖队列：β=0.507；P=0.003）。
我们的研究结果进一步证实了文献中提出的观点，即下肢功能与 HRQoL 的身体机能亚量表相关。然而，需要更大的纵向数据来评估下肢功能是否与 HRQoL 独立相关，其中包括营养和身体活动状况的潜在影响。
