H.K.E.S's Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Gulbarga-585105, India.
Department of Zoology, Vijayanagara Sri Krishnadevaraya University, Bellary-583105, India.
Pharm Nanotechnol. 2021;9(3):191-199. doi: 10.2174/2211738509666210319162415.
Silver nanoparticles have been widely used in the field of nanomedicine. A comprehensive understanding of their pharmacokinetics is crucial for proper risk assessment and safe biomedical applications.
The purpose of this study was to investigate the safety of silver nanoparticles by determining their potential toxicity following 28 days of administration in Sprague-Dawley rats.
The silver nanoparticles were administered by intravenous injection at the doses of 100, 200 and 500 μg/kg body weight for 28 consecutive days. Animals in the control group were received sterile water for injection. Each group consists of 10 male and 10 female rats.
No treatment-related effects were seen in any of the parameters monitored in rats given 100, 200 and 500 μg/kg body weight/day of silver nanoparticles.
The study proved that the use of up to 500 μg/kg body weight biosynthesized silver nanoparticles have no toxic effect on the target organs and found safe. However, the safety of the nanoparticles might be attributed to the covering of biological moieties on nanoparticles. Hence, the biofunctionalized nanoparticles can be safely used by selecting the required size and dose in medicines and drug delivery systems.
银纳米粒子已广泛应用于纳米医学领域。全面了解其药代动力学对于进行适当的风险评估和安全的生物医学应用至关重要。
本研究旨在通过在 Sprague-Dawley 大鼠中连续 28 天给药来确定其潜在毒性，从而评估银纳米粒子的安全性。
将银纳米粒子以 100、200 和 500μg/kg 体重的剂量通过静脉注射给药，连续 28 天。对照组动物给予无菌注射用水。每组包括 10 只雄性和 10 只雌性大鼠。
在给予 100、200 和 500μg/kg 体重/天的银纳米粒子的大鼠中，监测的任何参数均未观察到与治疗相关的影响。
该研究证明，使用高达 500μg/kg 体重的生物合成银纳米粒子对靶器官没有毒性作用，是安全的。然而，纳米粒子的安全性可能归因于纳米粒子表面覆盖有生物官能团。因此，可以通过选择药物和药物输送系统中所需的大小和剂量来安全使用这些功能化的纳米粒子。
