Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo (USP), Bandeirantes avenue 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Department of Health Sciences, Ribeirão Preto Medical School, University of Sao Paulo (USP), Bandeirantes avenue 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Clin Nutr ESPEN. 2021 Apr;42:105-116. doi: 10.1016/j.clnesp.2021.02.007. Epub 2021 Feb 24.
The study aimed to analyze the influence of chemotherapy on nutritional status and the phase angle (PhA) as nutritional indicator for breast cancer women undergoing chemotherapy.
A prospective study was performed. Women who were starting chemotherapy with no previous chemotherapy treatment were recruited. Quality of life (QoL) was collected using the EORTC QLQ-BR23 questionnaire. Bioelectrical impedance analysis, performance tests, and blood sample to albumin analyzes were collected at 2-time points: diagnosis (T0) and after 1 month of completion of therapy (T1). Mean, standard deviation, linear regression, and ANOVA in R were used to explore the results.
61 women were included. We did not find any changes in body composition. However, PhA, nutritional risk index (NRI), gait speed (GS), and handgrip strength (HGS) had expressive changes (p < 0.001). 75.4% of women had PhA values below the cut-off point of 5.6°, and the group that had a lower average of PhA also expressed low NRI. PhA was a nutritional status marker and its values were influenced by changes in NRI (p < 0.05).
We have found supporting evidence for chemotherapy treatment resulting in worsening of prognostic factors such as PhA, and yet PhA was related to no nutritional risk. Besides a higher prevalence of obesity, 80% of the sample showed some nutritional risk level, implying the possibility of a sub-notification candidate who might benefit, for instance, from nutritional intervention in obesity groups. Further investigation about this theme may improve health measures for the prevention and screening of disease among breast cancer.
本研究旨在分析化疗对营养状况和相位角（PhA）的影响，PhA 是用于评估接受化疗的乳腺癌女性的营养指标。
进行了一项前瞻性研究。招募了刚开始化疗且之前未接受过化疗的女性。使用 EORTC QLQ-BR23 问卷收集生活质量（QoL）。在 2 个时间点（T0 和治疗完成后 1 个月的 T1）采集生物电阻抗分析、表现测试和血液样本白蛋白分析。使用 R 中的均值、标准差、线性回归和方差分析来探索结果。
共纳入 61 名女性。我们没有发现身体成分有任何变化。然而，PhA、营养风险指数（NRI）、步态速度（GS）和手握力（HGS）有明显变化（p<0.001）。75.4%的女性的 PhA 值低于 5.6°的临界值，PhA 平均值较低的组也表示 NRI 较低。PhA 是一种营养状况标志物，其值受 NRI 变化的影响（p<0.05）。
我们已经发现了化疗治疗导致预后因素恶化的证据，如 PhA，但 PhA 与无营养风险相关。除了肥胖的高患病率外，80%的样本显示出某种营养风险水平，这意味着可能存在一个亚通知候选者，例如，肥胖人群的营养干预可能受益。进一步研究这个主题可能会改善乳腺癌的健康措施，以预防和筛查疾病。
