Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Giessen, Germany.
Clinic of Nephrology, Internal Medicine, University Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Giessen, Germany.
Int J Med Sci. 2021 Feb 3;18(7):1532-1540. doi: 10.7150/ijms.53728. eCollection 2021.
Neutrophil extracellular traps (NETs) have been implicated in host immune responses. Attempts have been made to examine how NETs affect the pathogenesis of complications such as autoimmune and vascular disorders. This study aimed to explore the relationship between NETs and vasculitis. The current study entailed the searching of PsycINFO, PubMed, Web of Science, and CINAHL for articles related to the research topic. The search terms and phrases included "vasculitis," "NETs," "neutrophil extracellular traps," "NETosis," and "pathogenesis." The search was limited to articles published between 2009 and 2019. Researchers have shown that NETs contribute to the pathogenesis of vasculitis through different mechanisms and processes, including renal failure and vascular damage. The protective effects of NETs have also been highlighted. Overall, some scholars have shown the effectiveness of using DNase I and the PAD4 inhibitor Cl-amidine to treat vasculitis by restricting NET formation. However, observations have been noted in only animal experimental models. Neutrophil hyperactivity and its role in vasculitis are not yet fully understood. More studies aiming to determine the accurate function of NETs in vasculitis pathogenesis, particularly in humans, should be undertaken. Intensive research on NETs and vasculitis can increase the knowledge of medical practitioners and contribute to the development of new treatment methods to enhance patient outcomes in the future.
中性粒细胞胞外诱捕网 (NETs) 已被牵涉到宿主免疫反应中。人们尝试研究 NETs 如何影响自身免疫和血管紊乱等并发症的发病机制。本研究旨在探讨 NETs 与血管炎之间的关系。目前的研究在 PsycINFO、PubMed、Web of Science 和 CINAHL 中搜索了与研究主题相关的文章。搜索的术语和短语包括“血管炎”、“NETs”、“中性粒细胞胞外诱捕网”、“NETosis”和“发病机制”。搜索范围限于 2009 年至 2019 年期间发表的文章。研究人员已经表明，NETs 通过不同的机制和过程，包括肾衰竭和血管损伤，促进血管炎的发病机制。NETs 的保护作用也得到了强调。总的来说，一些学者已经表明，通过限制 NET 形成，使用 DNase I 和 PAD4 抑制剂 Cl-amidine 治疗血管炎是有效的。然而，这些观察结果仅在动物实验模型中得到了证实。中性粒细胞活性亢进及其在血管炎中的作用尚未完全了解。应该进行更多的研究，以确定 NETs 在血管炎发病机制中的准确功能，特别是在人类中。对 NETs 和血管炎的深入研究可以增加医疗从业者的知识，并有助于开发新的治疗方法，以提高未来患者的治疗效果。
