Osadchiy Vadim, Mills Jesse N, Mayer Emeran A, Eleswarapu Sriram V
Division of Andrology, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles.
Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.
Curr Sex Health Rep. 2020 Sep;12(3):202-207. doi: 10.1007/s11930-020-00273-5. Epub 2020 Jul 17.
Focusing on studies published within the last decade, we review the literature on the seminal microbiome and male factor infertility. We highlight potential mechanisms by which microbes may impact fertility and underscore key limitations and clinical implications of these studies.
The seminal microbiome encompasses a metabolically and phylogenetically diverse group of microorganisms. was consistently associated with normal semen analysis parameters and fertility; was negatively associated with semen quality. These microbes may participate in a complex cross-talk with the host immune system, thereby modulating local and perhaps systemic inflammatory responses, impacting semen quality.
Research investigating the intersection between the seminal microbiome and male fertility is still in its infancy. Recent investigations have been exclusively cross-sectional, correlational studies, limiting the clinical applicability of published research. Prospective studies with more sophisticated methodologies are necessary.
聚焦过去十年发表的研究，我们回顾了有关精液微生物群和男性因素不育的文献。我们强调了微生物可能影响生育能力的潜在机制，并强调了这些研究的关键局限性和临床意义。
精液微生物群包含一组代谢和系统发育多样的微生物。与正常精液分析参数和生育能力始终相关；与精液质量呈负相关。这些微生物可能与宿主免疫系统参与复杂的相互作用，从而调节局部乃至全身的炎症反应，影响精液质量。
研究精液微生物群与男性生育之间交叉点的研究仍处于起步阶段。最近的研究均为横断面相关性研究，限制了已发表研究的临床适用性。需要采用更复杂方法的前瞻性研究。
