Hamedani Sahar Golpour-, Pourmasoumi Makan, Zarifi Sudiyeh Hejri, Askari Gholamreza, Jamialahmadi Tannaz, Bagherniya Mohammad, Sahebkar Amirhossein
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of medical science, Iran.
Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Heliyon. 2024 Jan 10;10(2):e24334. doi: 10.1016/j.heliyon.2024.e24334. eCollection 2024 Jan 30.
Due to an increase in the number of older people in recent years, neurodegenerative diseases as the most important age-related neurological disorders are considered as a great threat to human health. The treatment strategies for these disorders are symptomatic and there is no known definitive treatment; however, recently, several studies have investigated the effectiveness of some herbs and their components in limiting the progression and treatment of neurodegenerative disorders. In this study, we searched Medline (via PubMed), Scopus, Science Direct, and Google Scholar databases. The keywords used in the search were: saffron [title/abstract] or (saffron compound [title/abstract]) and (neurological disorders [title/abstract]), publication date range (2010-2023), and language (English). After applying inclusion and exclusion criteria, 30 articles remained. Of the 30 articles included in the study, six studies on the treatment of neurodegenerative disorders by saffron and its components were in the clinical trial phase, and 24 studies were in the preclinical phase. Saffron and its compounds can play an important role in inhibiting neuroinflammation and excitotoxic pathways, modulating autophagy and apoptosis, attenuating oxidative damage, and activating defensive antioxidant enzymes, resulting in neuroprotection against neurodegenerative diseases. Therefore, this study aimed to review the studies on the effects of saffron and its compounds on the treatment of neurodegenerative diseases.
由于近年来老年人数量的增加，神经退行性疾病作为最重要的与年龄相关的神经系统疾病，被视为对人类健康的巨大威胁。这些疾病的治疗策略只是对症治疗，尚无已知的确定性治疗方法；然而，最近，一些研究调查了某些草药及其成分在限制神经退行性疾病进展和治疗方面的有效性。在本研究中，我们检索了Medline（通过PubMed）、Scopus、Science Direct和谷歌学术数据库。检索中使用的关键词为：藏红花[标题/摘要]或（藏红花化合物[标题/摘要]）以及（神经系统疾病[标题/摘要]），出版日期范围（2010 - 2023年），语言（英语）。在应用纳入和排除标准后，剩余30篇文章。在该研究纳入的30篇文章中，有6项关于藏红花及其成分治疗神经退行性疾病的研究处于临床试验阶段，24项研究处于临床前阶段。藏红花及其化合物可在抑制神经炎症和兴奋性毒性途径、调节自噬和凋亡、减轻氧化损伤以及激活防御性抗氧化酶方面发挥重要作用，从而对神经退行性疾病产生神经保护作用。因此，本研究旨在综述关于藏红花及其化合物对神经退行性疾病治疗作用的研究。
