Ding Mei, Li Min, Yang Hailing
Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
Department of Clinical Laboratory, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
Exp Ther Med. 2021 May;21(5):457. doi: 10.3892/etm.2021.9888. Epub 2021 Mar 2.
The aim of the study was to analyze the clinical value of the combined detection of ischemia-modified albumin (IMA), D-dimer (D-D) and monocyte chemoattractant protein-1 (MCP-1) in the diagnosis of acute myocardial infarction (AMI). Altogether 87 patients with AMI from January 2017 to January 2018 were enrolled in the AMI group, and 82 patients without coronary artery disease were included in the control group. The serum levels of IMA, D-D, MCP-1, cardiac troponin (CTnT) and high-sensitivity C-reactive protein (hs-CRP) in the two groups were detected by ELISA. The blood lipids of the two groups and the levels of IMA, D-D, MCP-1 after treatment were detected. The association between IMA, D-D, MCP-1, CTnT, hs-CRP and blood lipid in patients with AMI was analyzed. The values of IMA, D-D, and MCP-1 alone and combined in the diagnosis of AMI were analyzed by ROC curve. The levels of IMA, D-D, MCP-1, CTnT and hs-CRP in the AMI group were significantly higher than those in the control group (P<0.05). The levels of IMA, D-D and MCP-1 in the patients with poor prognosis were significantly higher than those of the good prognosis group (P<0.05). The changes of IMA, D-D and MCP-1 levels were positively correlated with the levels of CTT and hs-CRP (P<0.05). The AUC, specificity and sensitivity of patients with AMI diagnosed with MCP-1 alone were 0.8084, 81.61 and 69.51%, respectively. Those of patients diagnosed by D-D were 0.7302, 59.77 and 81.71%, those of patients diagnosed by IMA alone were 0.7289, 58.62 and 80.49%, and those of patients detected by the combination of MCP-1, D-D and IMA were 0.9047, 58.62 and 93.90%. In conclusion, the levels of IMA, D-D and MCP-1 in AMI patients are higher than those in the control group. The levels of IMA, D-D and MCP-1 were positively correlated with CTnT and hs-CRP levels in AMI patients. Combined detection of IMA, D-D, and MCP-1 can improve the accuracy.
本研究旨在分析缺血修饰白蛋白（IMA）、D-二聚体（D-D）和单核细胞趋化蛋白-1（MCP-1）联合检测在急性心肌梗死（AMI）诊断中的临床价值。2017年1月至2018年1月共纳入87例AMI患者作为AMI组，82例无冠状动脉疾病的患者作为对照组。采用酶联免疫吸附测定法（ELISA）检测两组患者血清中IMA、D-D、MCP-1、心肌肌钙蛋白（CTnT）和高敏C反应蛋白（hs-CRP）水平。检测两组患者的血脂水平以及治疗后IMA、D-D、MCP-1水平。分析AMI患者IMA、D-D、MCP-1、CTnT、hs-CRP与血脂之间的相关性。通过ROC曲线分析IMA、D-D和MCP-1单独及联合检测对AMI的诊断价值。AMI组IMA、D-D、MCP-1、CTnT和hs-CRP水平显著高于对照组（P<0.05）。预后不良患者的IMA、D-D和MCP-1水平显著高于预后良好组（P<0.05）。IMA、D-D和MCP-1水平变化与CTT和hs-CRP水平呈正相关（P<0.05）。单独用MCP-1诊断AMI患者的曲线下面积（AUC）、特异性和敏感性分别为0.8084、81.61%和69.51%。用D-D诊断的患者分别为0.7302、59.77%和81.71%，单独用IMA诊断的患者分别为0.7289、58.62%和80.49%，用MCP-1、D-D和IMA联合检测的患者分别为0.9047、58.62%和93.90%。综上所述，AMI患者IMA、D-D和MCP-1水平高于对照组。AMI患者IMA、D-D和MCP-1水平与CTnT和hs-CRP水平呈正相关。联合检测IMA、D-D和MCP-1可提高诊断准确性。
