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以及在甲状腺乳头状癌中的表达。

and expression in papillary thyroid cancer.

作者信息

Sawicka-Gutaj Nadia, Shawkat Sara, Andrusiewicz Mirosław, Ziółkowska Paulina, Czarnywojtek Agata, Gut Paweł, Ruchała Marek

机构信息

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.

Department of Cell Biology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

出版信息

Oncol Lett. 2021 May;21(5):342. doi: 10.3892/ol.2021.12603. Epub 2021 Mar 2.

DOI:10.3892/ol.2021.12603
PMID:33747199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7967944/
Abstract

Recent studies have revealed the significant role of and genes in the development and aggressiveness of numerous types of malignant tumor. Therefore, the present study aimed to investigate the expression of and in papillary thyroid cancer, and to determine the correlation between the expression of these genes and clinical characteristics. Resected thyroid tissue samples from 62 patients with papillary thyroid cancer were investigated. Thyroid tissue derived from the healthy regions of removed nodular goiters from 30 patients served as the control group. Reverse transcription-quantitative PCR analysis was employed to detect relative mRNA expression levels. Primer sequences and TaqMan hydrolysis probe positions for and were determined using the Roche Universal ProbeLibrary Assay Design Center version 2.50. expression was detected in all thyroid cancer samples and in 83.3% of benign lesions. Notably, was revealed to be upregulated in thyroid cancer tissues compared with control tissues (P=0.0002). expression was positively correlated with tumor stage (P<0.0001; r=0.504), and multiple comparison analysis revealed that the highest expression of was detected in samples staged pT4 (P=0.0001). expression was detected in all thyroid cancer samples and in 96.7% of healthy thyroid tissues; notably, the expression levels were similar in both groups. In addition, there was no correlation between expression and the aggressiveness of papillary thyroid cancer. In conclusion, overexpression of the gene may be associated with the development of papillary thyroid cancer and may be a potential therapeutic target in papillary thyroid cancer.

摘要

近期研究揭示了[具体基因1]和[具体基因2]基因在多种恶性肿瘤的发生发展及侵袭性方面的重要作用。因此，本研究旨在探讨[具体基因1]和[具体基因2]在甲状腺乳头状癌中的表达情况，并确定这些基因的表达与临床特征之间的相关性。对62例甲状腺乳头状癌患者切除的甲状腺组织样本进行了研究。取自30例患者切除的结节性甲状腺肿健康区域的甲状腺组织作为对照组。采用逆转录定量PCR分析检测相对mRNA表达水平。使用罗氏通用探针库分析设计中心2.50版确定[具体基因1]和[具体基因2]的引物序列和TaqMan水解探针位置。[具体基因1]在所有甲状腺癌样本及83.3%的良性病变中均有表达。值得注意的是，与对照组织相比，[具体基因1]在甲状腺癌组织中呈上调表达（P = 0.0002）。[具体基因1]的表达与肿瘤分期呈正相关（P < 0.0001；r = 0.504），多重比较分析显示，在pT4期样本中[具体基因1]的表达最高（P = 0.0001）。[具体基因2]在所有甲状腺癌样本及96.7%的健康甲状腺组织中均有表达；值得注意的是，两组的表达水平相似。此外，[具体基因2]的表达与甲状腺乳头状癌的侵袭性之间无相关性。总之，[具体基因1]基因的过表达可能与甲状腺乳头状癌的发生发展有关，[具体基因1]可能是甲状腺乳头状癌的一个潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/896aa44df9c4/ol-21-05-12603-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/3e9c82bdcafb/ol-21-05-12603-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/80a80a072a51/ol-21-05-12603-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/a99bb00b9dce/ol-21-05-12603-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/70e8e4790f21/ol-21-05-12603-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/bfa0983e0167/ol-21-05-12603-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/f21444118730/ol-21-05-12603-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/5c4fab786616/ol-21-05-12603-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/baf9278a663e/ol-21-05-12603-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/896aa44df9c4/ol-21-05-12603-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/3e9c82bdcafb/ol-21-05-12603-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/80a80a072a51/ol-21-05-12603-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/a99bb00b9dce/ol-21-05-12603-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/70e8e4790f21/ol-21-05-12603-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/bfa0983e0167/ol-21-05-12603-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/f21444118730/ol-21-05-12603-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/5c4fab786616/ol-21-05-12603-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/baf9278a663e/ol-21-05-12603-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45eb/7967944/896aa44df9c4/ol-21-05-12603-g08.jpg

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