单次就诊时血压变异性与中风的关系。
Relation between Blood Pressure Variability within a Single Visit and Stroke.
作者信息
Ma Wei, Yang Ying, Qi Litong, Zhang Baowei, Meng Lei, Zhang Yan, Li Min, Huo Yong
机构信息
Division of Cardiology, Peking University First Hospital, Dahongluochang Street, Xicheng District, Beijing 100034, China.
出版信息
Int J Hypertens. 2021 Mar 2;2021:2920140. doi: 10.1155/2021/2920140. eCollection 2021.
Blood pressure variability (BPV) has been identified as an important risk factor for cardiovascular events. The white coat effect (WCE), which is measured as the first systolic blood pressure (SBP) measurement minus the mean of the second and third measurements, is a BPV indicator within a single visit. In total, 2,972 participants who had three measurements of BP within a single visit were included. The participants were divided into three groups based on their WCE percentiles: Group 1 (WCE, 2.5-97.5th percentiles of WCE), Group 2 (WCE, 0-2.4th percentiles of WCE), and Group 3 (WCE, 97.6-100th percentiles of WCE). A multiple logistic regression model was used to analyze the relationship between WCE and stroke after adjusting for cardiovascular disease risk factors. Compared with the WCE group, the OR for stroke in the WCE group was 2.78 (95% CI: 1.22, 6.36, =0.015). After adjusting for cardiovascular factors, OR increased to 3.12 (95% CI: 1.22, 7.96, =0.017). The OR of WCE for stroke was 0.93 (95%CI: 0.87, 0.99, =0.036). BPV within a single visit is associated with stroke. The value and direction of the change may be important as well.
血压变异性（BPV）已被确认为心血管事件的一个重要危险因素。白大衣效应（WCE），通过首次收缩压（SBP）测量值减去第二次和第三次测量值的平均值来衡量，是单次就诊时的一个BPV指标。总共纳入了2972名在单次就诊时进行了三次血压测量的参与者。根据他们的WCE百分位数将参与者分为三组：第1组（WCE，WCE的2.5 - 97.5百分位数），第2组（WCE，WCE的0 - 2.4百分位数），以及第3组（WCE，WCE的97.6 - 100百分位数）。在调整心血管疾病危险因素后，使用多元逻辑回归模型分析WCE与中风之间的关系。与WCE组相比，WCE组中风的比值比（OR）为2.78（95%置信区间：1.22，6.36，P = 0.015）。在调整心血管因素后，OR增加到3.12（95%置信区间：1.22，7.96，P = 0.017）。WCE导致中风的OR为0.93（95%置信区间：0.87，0.99，P = 0.036）。单次就诊时的BPV与中风相关。变化的值和方向可能也很重要。
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