Hariri Ali, Palma-Chavez Jorge, Wear Keith A, Pfefer T Joshua, Jokerst Jesse V, Vogt William C
Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
Photoacoustics. 2021 Feb 20;22:100245. doi: 10.1016/j.pacs.2021.100245. eCollection 2021 Jun.
As photoacoustic imaging (PAI) begins to mature and undergo clinical translation, there is a need for well-validated, standardized performance test methods to support device development, quality control, and regulatory evaluation. Despite recent progress, current PAI phantoms may not adequately replicate tissue light and sound transport over the full range of optical wavelengths and acoustic frequencies employed by reported PAI devices. Here we introduce polyacrylamide (PAA) hydrogel as a candidate material for fabricating stable phantoms with well-characterized optical and acoustic properties that are biologically relevant over a broad range of system design parameters. We evaluated suitability of PAA phantoms for conducting image quality assessment of three PAI systems with substantially different operating parameters including two commercial systems and a custom system. Imaging results indicated that appropriately tuned PAA phantoms are useful tools for assessing and comparing PAI system image quality. These phantoms may also facilitate future standardization of performance test methodology.
随着光声成像（PAI）开始走向成熟并进入临床应用阶段，需要有经过充分验证的标准化性能测试方法来支持设备开发、质量控制和监管评估。尽管最近取得了进展，但目前的PAI体模可能无法在已报道的PAI设备所采用的整个光学波长和声学频率范围内充分复制组织的光和声传播。在此，我们引入聚丙烯酰胺（PAA）水凝胶作为一种候选材料，用于制造具有良好表征的光学和声学特性的稳定体模，这些特性在广泛的系统设计参数范围内与生物学相关。我们评估了PAA体模对三个具有显著不同操作参数的PAI系统（包括两个商业系统和一个定制系统）进行图像质量评估的适用性。成像结果表明，经过适当调整的PAA体模是评估和比较PAI系统图像质量的有用工具。这些体模还可能促进未来性能测试方法的标准化。
