Demetter Pieter, Maréchal Raphaël, Puleo Francesco, Delhaye Myriam, Debroux Sébastien, Charara Fadi, Gomez Galdon Maria, Van Laethem Jean-Luc, Verset Laurine
Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Department of Gastroenterology, CHU Tivoli, La Louvière, Belgium.
Front Oncol. 2021 Mar 5;11:630086. doi: 10.3389/fonc.2021.630086. eCollection 2021.
Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.
胰腺未分化癌是一种侵袭性强但罕见的肿瘤，曾使用过其他几个术语来描述其组织学表现。此外，由于破骨细胞样巨细胞可能伴随胰腺未分化癌出现，世界卫生组织分类将伴有破骨细胞样巨细胞的未分化癌（UC-OGC）与普通未分化癌区分开来，因为二者在组织病理学和临床方面存在一些差异。UC-OGC最初被认为与浸润性导管胰腺腺癌相比预后更差，因为它在诊断时通常无法切除，即使完全切除也往往迅速复发。然而，当真正的UC-OGG从其他间变性癌中仔细分离出来时，就会清楚地发现UC-OGC的行为更具惰性，尤其是纯UC-OGC。本综述总结了目前关于UC-OGC的知识。
