Avula Uma Mahesh R, Melki Lea, Kushner Jared S, Liang Stephanie, Wan Elaine Y
Division of Nephrology, University of Mississippi, Jackson, MS, United States.
Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Front Cardiovasc Med. 2021 Mar 5;8:649489. doi: 10.3389/fcvm.2021.649489. eCollection 2021.
Reentrant cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF) are common cardiac arrhythmias that account for substantial morbidity and mortality throughout the world. However, the mechanisms and optimal ablation treatment strategies for such arrhythmias are still unclear. Using 2D optical mapping of a mouse model with AF and VF, we have identified regional heterogeneity of the action potential duration (APD) in the atria and ventricles of the heart as key drivers for the initiation and persistence of reentry. The purpose of this paper is to discuss theoretical patterns of dispersion, demonstrate patterns of dispersion seen in our mouse model and discuss the computational analysis of APD dispersion patterns. These analyses and discussions may lead to better understanding of dispersion patterns in patients with these arrhythmias, as well as help comprehend whether and how reducing dispersion can lead to arrhythmia risk stratification and treatment strategies for arrhythmias.
折返性心律失常，如心房颤动（AF）和心室颤动（VF），是常见的心律失常，在全球范围内导致了相当高的发病率和死亡率。然而，此类心律失常的机制和最佳消融治疗策略仍不明确。通过对心房颤动和心室颤动小鼠模型进行二维光学标测，我们已确定心脏心房和心室动作电位时程（APD）的区域异质性是折返起始和持续的关键驱动因素。本文旨在讨论离散的理论模式，展示在我们的小鼠模型中观察到的离散模式，并讨论动作电位时程离散模式的计算分析。这些分析和讨论可能有助于更好地理解这些心律失常患者的离散模式，以及帮助理解减少离散是否以及如何能够实现心律失常风险分层和制定心律失常治疗策略。
