Arafa El-Shaimaa A, Shurrab Noura T, Buabeid Manal A
Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE.
Adv Pharmacol Pharm Sci. 2021 Mar 5;2021:4709818. doi: 10.1155/2021/4709818. eCollection 2021.
Chemotherapeutics can induce oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, and abnormalities in neurotransmitter metabolism leading to toxicity. Because there have been no therapeutic strategies developed to target inflammation and oxidative stress, there is a continuing need for new and improved therapy. As a result, there has been increasing interest in complementary and alternative medicine with anticancer potential. Studies have shown that the antioxidant activities and anti-inflammatory effects of citrus fruits are promising natural phytochemicals in the development of new anticancer agents. Tangeretin is a naturally polymethoxylated flavone compound extracted from the citrus peel that has shown significant intestinal absorption and adequate bioavailability, with the added benefit of promoting longevity. In addition, tangeretin is known to exhibit considerable selective toxicity to many types of cancer cell proliferation such as ovarian, brain, blood, and skin cancer. Evidence indicates that tangeretin acts through several mechanisms including growth inhibition, induction of apoptosis, autophagy, antiangiogenesis, and estrogenic-like effects. Furthermore, tangeretin works through mitigating levels of inflammatory mediators in the immune system. Using tangeretin in combination with clinically applied anticancer drugs could be a good strategy for increasing the efficiency of these agents and protecting noncancerous cells from damage caused by chemotherapy. The purpose of this review is to highlight the protective effects of a novel natural product, tangeretin against chemotherapeutic-induced toxicity. The development of chemoprevention strategies can lead to significant health care improvement in cancer survivors. Thus, study outcomes may attract more investigators to conduct tangeretin-related research and find out potentially significant impacts on health care of cancer patients and decreased health problems associated with chemotherapeutics-induced toxicity.
化疗药物可诱导氧化应激、炎症、细胞凋亡、线粒体功能障碍以及神经递质代谢异常，从而导致毒性。由于尚未开发出针对炎症和氧化应激的治疗策略，因此持续需要新的、改进的治疗方法。结果，人们对具有抗癌潜力的补充和替代医学越来越感兴趣。研究表明，柑橘类水果的抗氧化活性和抗炎作用是开发新型抗癌药物中很有前景的天然植物化学物质。橘皮素是一种从柑橘皮中提取的天然多甲氧基黄酮化合物，已显示出显著的肠道吸收和足够的生物利用度，还有促进长寿的额外益处。此外，已知橘皮素对多种类型的癌细胞增殖具有相当大的选择性毒性，如卵巢癌、脑癌、血癌和皮肤癌。有证据表明，橘皮素通过多种机制发挥作用，包括生长抑制、诱导细胞凋亡、自噬、抗血管生成和类雌激素样作用。此外，橘皮素通过降低免疫系统中炎症介质的水平起作用。将橘皮素与临床应用的抗癌药物联合使用可能是提高这些药物疗效并保护非癌细胞免受化疗损伤的良好策略。本综述的目的是强调一种新型天然产物橘皮素对化疗诱导毒性的保护作用。化学预防策略的发展可显著改善癌症幸存者的医疗保健状况。因此，研究结果可能会吸引更多研究人员开展与橘皮素相关的研究，并发现其对癌症患者医疗保健的潜在重大影响以及减少与化疗诱导毒性相关的健康问题。
