用于促进伤口加速愈合的新型微环境的研发。
Development of novel microenvironments for promoting enhanced wound healing.
作者信息
Scull Grant, Brown Ashley C
机构信息
Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC 27695.
Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695.
出版信息
Curr Tissue Microenviron Rep. 2020 Sep;1(3):73-87. doi: 10.1007/s43152-020-00009-6. Epub 2020 Jul 29.
PURPOSE OF REVIEW
Nonhealing wounds are a significant issue facing the healthcare industry. Materials that modulate the wound microenvironment have the potential to improve healing outcomes.
RECENT FINDINGS
A variety of acellular and cellular scaffolds have been developed for regulating the wound microenvironment, including materials for controlled release of antimicrobials and growth factors, materials with inherent immunomodulative properties, and novel colloidal-based scaffolds. Scaffold construction methods include electrospinning, 3D printing, decellularization of extracellular matrix, or a combination of techniques. Material application methods include layering or injecting at the wound site.
SUMMARY
Though these techniques show promise for repairing wounds, all material strategies thus far struggle to induce regeneration of features such as sweat glands and hair follicles. Nonetheless, innovative technologies currently in the research phase may facilitate future attainment of these features. Novel methods and materials are constantly arising for the development of microenvironments for enhanced wound healing.
综述目的
难愈合伤口是医疗行业面临的一个重大问题。调节伤口微环境的材料有可能改善愈合效果。
最新发现
已开发出多种无细胞和细胞支架来调节伤口微环境，包括用于控释抗菌剂和生长因子的材料、具有固有免疫调节特性的材料以及新型胶体基支架。支架构建方法包括静电纺丝、3D打印、细胞外基质去细胞化或技术组合。材料应用方法包括在伤口部位分层或注射。
总结
尽管这些技术在伤口修复方面显示出前景，但迄今为止所有的材料策略都难以诱导汗腺和毛囊等特征的再生。尽管如此，目前处于研究阶段的创新技术可能有助于未来实现这些特征。用于开发促进伤口愈合的微环境的新方法和材料不断涌现。
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