Ding Xinran, Xie Sujie, Zhang Wei, Zhu Yushu, Xu Dayuan, Xian Shuyuan, Sun Hanlin, Guo Xinya, Li Yixu, Lu Jianyu, Tong Xirui, Huang Runzhi, Ji Shizhao, Xia Zhaofan
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, China.
Regen Ther. 2025 Jan 16;28:371-382. doi: 10.1016/j.reth.2024.12.018. eCollection 2025 Mar.
With the continuous advancement of materials science, cell biology, and biotechnology, tissue engineering has introduced novel solutions to traditional wound healing approaches, particularly demonstrating significant potential in addressing complex or non-healing wounds. One of the key technologies in this field, dermal scaffolds, serve as wound coverage materials that mimic the structural framework of the dermis. They primarily assume the function of extracellular matrix, providing space for cell attachment, migration, and proliferation, thus supporting cellular growth and regulating multiple biological processes in healing. Tissue engineering utilizes combinations of natural or synthetic scaffolds, seeded cells, or growth factors to induce distinct effects in angiogenesis, extracellular matrix deposition, and functional recovery. Therefore, various bioengineered dermal scaffolds hold significant potential for clinical translation in wound healing. This review outlines various extracellular matrix molecules utilized in the development of dermal scaffolds, emphasizes recent progress in cell- and growth factor-modified scaffolds, and discusses the challenges and future perspectives in this evolving field.
随着材料科学、细胞生物学和生物技术的不断进步，组织工程为传统伤口愈合方法带来了新的解决方案，尤其在解决复杂或难愈合伤口方面显示出巨大潜力。该领域的关键技术之一——真皮支架，作为模仿真皮结构框架的伤口覆盖材料。它们主要承担细胞外基质的功能，为细胞附着、迁移和增殖提供空间，从而支持细胞生长并调节愈合过程中的多种生物学过程。组织工程利用天然或合成支架、接种细胞或生长因子的组合，在血管生成、细胞外基质沉积和功能恢复方面诱导不同的效果。因此，各种生物工程真皮支架在伤口愈合的临床转化中具有巨大潜力。本综述概述了用于真皮支架开发的各种细胞外基质分子，强调了细胞和生长因子修饰支架的最新进展，并讨论了这个不断发展的领域中的挑战和未来前景。
