Kirshon B, Lee W, Cotton D B
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Obstet Gynecol. 1988 Jun;71(6 Pt 2):1032-4.
Severe hyperemesis gravidarum has often been associated with elevated thyroid function. However, it has not been determined whether establishing euthyroidism will result in prompt resolution of nausea and vomiting. We report here a gravida with severe intractable hyperemesis gravidarum requiring four months of parenteral hyperalimentation. This patient consistently demonstrated biochemical evidence of hyperthyroidism with no symptoms and signs other than nausea and vomiting. Although no parenteral form of antithyroid medication is commercially available, methimazole suppositories were developed and administered until thyroid function tests normalized. Despite euthyroidism, nausea and vomiting continued unabated. After delivery, both the elevated thyroid function and the nausea and vomiting resolved within three days.
重度妊娠剧吐常与甲状腺功能亢进有关。然而，甲状腺功能恢复正常是否能迅速缓解恶心和呕吐尚未确定。我们在此报告一名患有重度顽固性妊娠剧吐的孕妇，她需要接受四个月的胃肠外营养。该患者一直有甲状腺功能亢进的生化证据，除恶心和呕吐外无其他症状和体征。尽管市面上没有胃肠外使用的抗甲状腺药物，但我们研发并使用了甲巯咪唑栓剂，直至甲状腺功能测试恢复正常。尽管甲状腺功能恢复正常，但恶心和呕吐仍未减轻。分娩后，甲状腺功能亢进以及恶心和呕吐在三天内均得到缓解。
