Istanbul University-Cerrahpasa, Faculty of Engineering, Department of Chemistry, Avcilar 34320, Istanbul, Turkey.
Istanbul University, Faculty of Science, Department of Chemistry, Fatih 34126, Istanbul, Turkey.
Food Chem. 2021 Aug 15;353:129337. doi: 10.1016/j.foodchem.2021.129337. Epub 2021 Feb 27.
Natural deep eutectic solvents (NADES) have recently come to the fore as new green solvents for foods, cosmetics and pharmaceuticals due to their unique solvation power and low toxicity. Turmeric extracts were prepared using the microwave assisted extraction method (MAE) using five NADES containing binary combinations of choline chloride, lactic acid, fructose, and sucrose. The MAE method was optimized and modeled by using response surface methodology to obtain maximum total antioxidant capacity (TAC) and curcumin contents (CC) in extracts for each NADES. All NADES extracts, except NADES-1 containing fructose and cholin chloride, exhibited higher TAC and CC than those in 80% methanol:water which was the preferred solvent in literature. NADES solvents did not interfere with subsequent antioxidant capacity measurements using the CUPRAC method. The proposed MAE is a potentially efficient and sustainable procedure in pharmaceutical and food industries for the extraction of antioxidants and curcumin from turmeric.
天然深共晶溶剂（NADES）由于其独特的溶解能力和低毒性，最近作为食品、化妆品和制药行业的新型绿色溶剂而备受关注。使用五种包含胆碱氯化物、乳酸、果糖和蔗糖的二元组合的 NADES 通过微波辅助提取方法（MAE）制备姜黄提取物。通过响应面法对 MAE 方法进行了优化和建模，以获得每种 NADES 提取物中最大的总抗氧化能力（TAC）和姜黄素含量（CC）。除了含有果糖和胆碱氯化物的 NADES-1 之外，所有 NADES 提取物的 TAC 和 CC 均高于文献中首选溶剂 80%甲醇：水。NADES 溶剂不会干扰使用 CUPRAC 方法进行的后续抗氧化能力测量。所提出的 MAE 是制药和食品工业中从姜黄中提取抗氧化剂和姜黄素的一种潜在有效和可持续的方法。
