Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China.
J Cosmet Dermatol. 2021 Oct;20(10):3227-3235. doi: 10.1111/jocd.14089. Epub 2021 Apr 20.
Platelet rich plasma (PRP) has been accepted as a potential therapy for treating androgenetic alopecia (AGA).
To fully clarify the underling molecular mechanisms of PRP action on hair growth and promote its clinical applications.
In this study, we used mice models and protein biochip to explore the specific mechanisms of PRP regulating hair growth. Then, we performed a randomized, placebo-controlled, double-blind, half-head study of 52 AGA patients to verify the therapeutic efficacy of PRP in Chinese AGA patients.
The results confirmed that PRP treatment boosted hair regrowth, accelerated hair cycling, and the effect sustained for more than one hair cycle in mice. Protein biochip evaluation confirmed remarkably upregulated β-Catenin, PDGF, and AKT signaling and repressed p53 signaling in PRP injection group. Clinically, mean hair count, density, diameter, and anagen hair ratio in PRP group showed a significant improvement at 6 month comparing to control side.
Overall, we elucidated the specific molecular mechanism of PRP action on hair growth and proved the therapeutic efficacy and safety of PRP in Chinese AGA patients.
富含血小板的血浆 (PRP) 已被接受为治疗雄激素性脱发 (AGA) 的潜在疗法。
充分阐明 PRP 促进头发生长的潜在分子机制，促进其临床应用。
在这项研究中，我们使用小鼠模型和蛋白质生物芯片来探索 PRP 调节头发生长的具体机制。然后，我们对 52 例 AGA 患者进行了一项随机、安慰剂对照、双盲、半头研究，以验证 PRP 在中国人 AGA 患者中的治疗效果。
结果证实 PRP 治疗可促进毛发生长，加速毛发生长周期，并且在小鼠中效果持续超过一个毛发生长周期。蛋白质生物芯片评估证实 PRP 注射组中 β-Catenin、PDGF 和 AKT 信号显著上调，p53 信号受到抑制。临床上，PRP 组的平均头发计数、密度、直径和生长期毛发比例在 6 个月时与对照组相比均有显著改善。
总的来说，我们阐明了 PRP 对头发生长作用的具体分子机制，并证明了 PRP 在中国人 AGA 患者中的治疗效果和安全性。
