血小板裂解液促进毛发生长：体外和体内机制及随机、对照试验。
Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial.
机构信息
Department of Plastic and Aesthetic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, China; Department of Plastic and Aesthetic Surgery, Guiyang First People's Hospital, Guiyang, China.
Department of Plastic and Aesthetic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, China.
出版信息
Biomed Pharmacother. 2023 May;161:114517. doi: 10.1016/j.biopha.2023.114517. Epub 2023 Mar 11.
BACKGROUND
Platelet lysate (PL), a novel platelet derivative, has been widely used in regenerative medicine and is a potential therapy for improving hair growth. It is necessary to fully clarify the potential mechanism and evaluate preliminary clinical effect of PL on hair growth.
METHODS
We used the C57BL/6 model, organ-cultured hair follicles, and RNA-seq analysis to explore the mechanisms of PL regulating hair growth. Then, we performed a randomized, controlled, double-blind study of 107 AGA patients to verify the therapeutic efficacy of PL.
RESULTS
The results confirmed that PL improved hair growth and accelerated hair cycling in mice. Organ-cultured hair follicle evaluation confirmed that PL prolonged anagen remarkably and down-regulated IL-6, C-FOS, and p-STAT5a. Clinically, diameter, hair counts, absolute anagen counts and changes from baseline in the PL group showed a significant improvement at 6 months.
CONCLUSIONS
We elucidated the specific molecular mechanism of PL action on hair growth and proved equal changes in hair follicle performance after PL vs PRP in AGA patients. This study provided novel knowledge of PL, making it ideal for AGA.
背景
血小板裂解液（PL）是一种新型血小板衍生物，已广泛应用于再生医学，是一种潜在的促进毛发生长的治疗方法。有必要充分阐明 PL 促进毛发生长的潜在机制，并评估其初步临床疗效。
方法
我们使用 C57BL/6 模型、毛囊器官培养和 RNA-seq 分析来探索 PL 调节毛发生长的机制。然后，我们对 107 例 AGA 患者进行了一项随机、对照、双盲研究，以验证 PL 的治疗效果。
结果
结果证实 PL 可改善小鼠的毛发生长并加速毛发周期。毛囊器官培养评估证实，PL 可显著延长生长期，并下调 IL-6、C-FOS 和 p-STAT5a。临床上，PL 组在 6 个月时的直径、头发计数、绝对生长期计数和自基线的变化均显示出显著改善。
结论
我们阐明了 PL 促进毛发生长的具体分子机制，并证明了 PL 与 PRP 在 AGA 患者中的毛囊性能变化相当。本研究为 PL 在 AGA 中的应用提供了新的知识，使其成为一种理想的治疗方法。
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