Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Vasc Access. 2021 Nov;22(6):969-978. doi: 10.1177/11297298211003003. Epub 2021 Mar 22.
The objective of this systematic review is to evaluate the safety ad feasibility of the totally implantable vascular access devices (TIVADs) flushed more than 4 weeks. We searched the following electronic databases from the date their build-up to February 2020: PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL. The final selection resulted in 14 trials fulfilling the inclusion criteria and being included in our review. A pooled frequency of port-related late complications with longer flushing intervals (>4 weeks) was 8.0%, and the pooled frequency of occlusions, infections, and mechanical complications was 5.0%, 2.0%, and 3.0%, respectively. Then, we compared the frequency of port-related complications between standard and longer flushing intervals. There were no differences between the group's changes in the frequency of total late complications, occlusions, infections, and mechanical complications. This systematic review and meta-analysis demonstrates that longer flushing intervals for ports are safe. However, more prospective, power appropriated randomized trials are needed to explore the specific flushing time for ports.
本系统评价的目的是评估完全植入式血管通路装置（TIVAD）超过 4 周冲洗的安全性和可行性。我们从建立日期到 2020 年 2 月搜索了以下电子数据库：PubMed、EMBASE、The Cochrane Central Register of Controlled Trials（CENTRAL）和 CINAHL。最终选择了 14 项符合纳入标准并纳入本综述的试验。更长冲洗间隔（>4 周）时与端口相关的晚期并发症的合并频率为 8.0%，而与端口相关的阻塞、感染和机械并发症的合并频率分别为 5.0%、2.0%和 3.0%。然后，我们比较了标准冲洗间隔和更长冲洗间隔之间与端口相关的并发症的频率。两组晚期总并发症、阻塞、感染和机械并发症的频率变化没有差异。本系统评价和荟萃分析表明，延长端口冲洗间隔是安全的。然而，需要更多前瞻性、适当功率的随机试验来探索特定的端口冲洗时间。
