多用途导航者：前额叶对空间导航的贡献。
The Versatile Wayfinder: Prefrontal Contributions to Spatial Navigation.
机构信息
Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, UK; Institute of Behavioural Neuroscience, Department of Experimental Psychology, Division of Psychology and Language sciences, University College London, UK.
Institute of Behavioural Neuroscience, Department of Experimental Psychology, Division of Psychology and Language sciences, University College London, UK.
出版信息
Trends Cogn Sci. 2021 Jun;25(6):520-533. doi: 10.1016/j.tics.2021.02.010. Epub 2021 Mar 19.
The prefrontal cortex (PFC) supports decision-making, goal tracking, and planning. Spatial navigation is a behavior that taxes these cognitive processes, yet the role of the PFC in models of navigation has been largely overlooked. In humans, activity in dorsolateral PFC (dlPFC) and ventrolateral PFC (vlPFC) during detours, reveal a role in inhibition and replanning. Dorsal anterior cingulate cortex (dACC) is implicated in planning and spontaneous internally-generated changes of route. Orbitofrontal cortex (OFC) integrates representations of the environment with the value of actions, providing a 'map' of possible decisions. In rodents, medial frontal areas interact with hippocampus during spatial decisions and switching between navigation strategies. In reviewing these advances, we provide a framework for how different prefrontal regions may contribute to different stages of navigation.
前额皮质（prefrontal cortex，PFC）支持决策、目标追踪和规划。空间导航是一种需要这些认知过程的行为，但 PFC 在导航模型中的作用在很大程度上被忽视了。在人类中，在迂回时背外侧前额皮质（dorsolateral prefrontal cortex，dlPFC）和腹外侧前额皮质（ventrolateral prefrontal cortex，vlPFC）的活动揭示了其在抑制和重新规划中的作用。背侧前扣带皮层（dorsal anterior cingulate cortex，dACC）参与计划和自发的路线内生成变化。眶额皮层（orbitofrontal cortex，OFC）将环境的表示与行动的价值结合起来，提供了一个可能决策的“地图”。在啮齿动物中，内侧额区在空间决策和导航策略之间切换时与海马体相互作用。在回顾这些进展时，我们提供了一个框架，说明不同的前额区域如何有助于导航的不同阶段。
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