Student Research Committee, School of Dentistry, Babol University of Medical Sciences, Iran.
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Iran.
Dent Med Probl. 2021 Jan-Mar;58(1):27-30. doi: 10.17219/dmp/126360.
Recurrent aphthous stomatitis (RAS) is one of the most common recurrent ulcerations in the oral mucosa, the etiology of which has not been elucidated; the immune system dysfunction may play an important role in the pathogenesis of RAS. The anti-inflammatory and regulatory role of vitamin D in the functioning of the immune system is well-documented.
This study aimed to evaluate and compare the serum levels of vitamin D between patients with RAS and healthy controls.
In this case-control study, 43 patients with minor RAS and 43 healthy controls were included. Two groups were matched in terms of age and sex. Blood samples were obtained from all participants. The serum levels of vitamin D were measured with the use of the enzyme-linked immunosorbent assay (ELISA) in patient and control groups. The data was analyzed using the SPSS for Windows software, v. 17.0, with the independent samples t test and the Mann-Whitney test. A p-value of <0.05 was considered statistically significant.
The mean serum level of vitamin D in the control group was significantly higher than that in the case group (22.59 ±16.06 ng/mL vs 13.19 ±8.19 ng/mL, respectively; p = 0.002).
The serum levels of vitamin D are lower in patients with RAS in comparison with healthy controls.
复发性阿弗他口炎（RAS）是口腔黏膜最常见的复发性溃疡之一，其病因尚未阐明；免疫系统功能障碍可能在 RAS 的发病机制中起重要作用。维生素 D 在免疫系统中的抗炎和调节作用已有充分的文献记载。
本研究旨在评估和比较 RAS 患者与健康对照组之间的血清维生素 D 水平。
在这项病例对照研究中，纳入了 43 例轻型 RAS 患者和 43 名健康对照者。两组在年龄和性别方面相匹配。从所有参与者中采集血样。使用酶联免疫吸附试验（ELISA）测量患者组和对照组的血清维生素 D 水平。使用 SPSS for Windows 软件，v. 17.0 对数据进行分析，采用独立样本 t 检验和 Mann-Whitney 检验。p 值<0.05 被认为具有统计学意义。
对照组的平均血清维生素 D 水平明显高于病例组（分别为 22.59 ±16.06 ng/mL 和 13.19 ±8.19 ng/mL；p = 0.002）。
与健康对照组相比，RAS 患者的血清维生素 D 水平较低。
