Krawiecka Ewa, Ślebioda Zuzanna, Szponar Elżbieta, Kowalska Anna, Dorocka-Bobkowska Barbara
Department of Oral Mucosa Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Department of Nucleic Acid Function, Polish Academy of Sciences, Poznan, Poland.
Postepy Dermatol Alergol. 2017 Dec;34(6):612-617. doi: 10.5114/pdia.2017.69683. Epub 2017 Dec 31.
Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease.
To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism.
Sixty-six patients with RAS and 66 controls were examined. Immunomodulatory or immunosuppressive treatment and other ulcerative oral diseases were used as exclusion criteria. The severity of RAS was assessed according to the clinical classification of the disease, the number of lesions per flare-up and the length of intervals between the attacks. The serum vitamin D level was established in each participant.
The mean serum vitamin D (25(OH)D) levels were found to be 16.81 ng/ml in the study group and 19.22 ng/ml in the control group, with no statistically significant difference between the two groups. In the study group, 5 (7.6%) participants were diagnosed with the "normal" vitamin D levels, while 16 (24.2%) had "insufficient" levels and 45 (68.2%) had "deficient" levels. The corresponding distribution in the control group was 8 (12.1%), 18 (27.3%) and 40 (60.6%), respectively. There was no statistical significance in the difference of vitamin D deficits between the study and the control groups. No correlation was detected between the severity of RAS and the serum vitamin D level.
Vitamin D does not seem to be a trigger factor for RAS occurrence and does not appear to influence the severity of the disease in the studied group.
复发性阿弗他口炎（RAS）是一种常见的慢性炎症性口腔黏膜疾病，病因不明。然而，免疫反应失调似乎在该疾病中起重要作用。
鉴于维生素D在人体中可能具有免疫调节功能，评估RAS患者的维生素D状态及其对RAS严重程度的影响。
对66例RAS患者和66例对照者进行检查。将免疫调节或免疫抑制治疗以及其他溃疡性口腔疾病作为排除标准。根据疾病的临床分类、每次发作时的病损数量以及发作间隔时间来评估RAS的严重程度。测定每位参与者的血清维生素D水平。
研究组的平均血清维生素D（25(OH)D）水平为16.81 ng/ml，对照组为19.22 ng/ml，两组之间无统计学显著差异。在研究组中，5例（7.6%）参与者被诊断为维生素D水平“正常”，16例（24.2%）为“不足”，45例（68.2%）为“缺乏”。对照组的相应分布分别为8例（12.1%）、18例（27.3%）和40例（60.6%）。研究组和对照组之间维生素D缺乏的差异无统计学意义。未检测到RAS严重程度与血清维生素D水平之间存在相关性。
维生素D似乎不是RAS发生的触发因素，且在研究组中似乎不影响该疾病的严重程度。
