Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nutr Cancer. 2022;74(2):565-578. doi: 10.1080/01635581.2021.1903950. Epub 2021 Mar 24.
This study evaluated changes in fatty acids from sera, red blood cells, and colonic biopsies from a phase Ib clinical trial of personalized ω-3 fatty acid dosing in 47 healthy volunteers. The trial aimed to reduce colonic prostaglandin E (PGE), a pro-inflammatory product of arachidonic acid (AA) oxidation. The personalized doses ranged 2-10 grams/day (54% eicosapentaenoic acid, EPA, 24% other ω-3 fatty acids). In colon, increases in ω-3 highly unsaturated fatty acids (HUFA) and EPA:AA ratios each were correlated with decreases in PGE. Changes in either colonic EPA:AA ratios or ω-3 HUFA were significantly correlated with changes in the same fatty acid measures in red blood cells or serum. The only blood-based measure significantly correlated with changes in colonic PGE was change in red blood cell ω-3 HUFA (ρ = -0.39), and the increase in red blood cell ω-3 HUFA was significantly greater in participants who had at least a median reduction in colonic PGE vs. those who did not. In summary, fatty acid changes in blood did reflect fatty acid changes in the colon, but additional factors will be needed for optimizing dosing models that seek to predict the anti-inflammatory effects of ω-3 fatty acids on the colon.
本研究评估了 47 名健康志愿者进行的个体化 ω-3 脂肪酸剂量的 Ib 期临床试验中血清、红细胞和结肠活检组织中脂肪酸的变化。该试验旨在减少结肠前列腺素 E (PGE)，即花生四烯酸 (AA)氧化的促炎产物。个体化剂量范围为 2-10 克/天（54%二十碳五烯酸，EPA，24%其他 ω-3 脂肪酸）。在结肠中，ω-3 高度不饱和脂肪酸 (HUFA)和 EPA:AA 比值的增加与 PGE 的减少相关。结肠中 EPA:AA 比值或 ω-3 HUFA 的变化与红细胞或血清中相同脂肪酸测量值的变化显著相关。与结肠 PGE 变化显著相关的唯一血液测量值是红细胞 ω-3 HUFA 的变化（ρ=-0.39），与结肠 PGE 至少有中位数减少的参与者相比，红细胞 ω-3 HUFA 的增加明显更大。总之，血液中脂肪酸的变化确实反映了结肠中脂肪酸的变化，但需要额外的因素来优化旨在预测 ω-3 脂肪酸对结肠抗炎作用的剂量模型。
