Kaur Harpreet, Gosavi Suchitra, Hazarey Vinay K, Gupta Vandana, Bhadauria Upendra Singh, Kherde Pooja
All India Institute of Medical Sciences, Centre for Dental Education and Research, Division of Oral Pathology and Microbiology, New Delhi, India; Government Dental College & Hospital, Department of Oral Pathology, Nagpur, India.
Government Dental College & Hospital, Department of Oral Pathology, Nagpur, India.
Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 1(Suppl 1):S3-S13. doi: 10.1016/j.bjorl.2021.02.006. Epub 2021 Mar 7.
The classification of odontogenic tumors has been revised from time to time in order to provide unified terminology. This reclassification had considerable impact on their prevalence and frequency distribution.
This study was aimed to emphasize impact of changing classification systems on prevalence and relative frequency of odontogenic tumors. The secondary objective was to analyze demographics of various histological types of odontogenic tumors in comparison to published literature. Review of Indian studies (1992-2020) elaborating frequency of odontogenic tumors is summarized in the end.
This was a hospital-based retrospective study wherein case files of odontogenic tumors diagnosed from 1990 to 2019 period were retrieved. The classification system used originally at the time of diagnosis was retained and prevalence of odontogenic tumors in three different periods (1990-2004, 2005-2016 and 2017-2019) was compared. Further, prevalence, frequency distribution and demographics of all these tumors (1990-2019) were analyzed using latest World Health Organization 2017 classification.
A total of 345 odontogenic tumors was diagnosed as per World Health Organization 2017 system of classification from 1990 to 2019. 96.81% tumors were benign and 3.81% constituted malignant odontogenic tumors. However, there was marked increase in prevalence of odontogenic tumors in 2005-2016 (6.2%) period as compared to 1990-2004 (3.87%) and 2017-2019 (3.47%). Ameloblastoma remained the most common tumor in three different periods, whereas keratocystic odontogenic tumor became second commonest tumor in 2005-2016 as compared to odontoma in 1990-2004 and adenomatoid odontogenic tumor in 2017-2019.
The continuous evolving systems of classification may partly be responsible for inconsistency in odontogenic tumors, with inclusion of keratocystic odontogenic tumor,and has marked impact on prevalence and frequency distribution of odontogenic tumors. The geographical variations in demographics of odontogenic tumors might reflect genetic and environment influence; however it requires elucidation by further studies.
牙源性肿瘤的分类不时进行修订，以提供统一的术语。这种重新分类对其患病率和频率分布产生了相当大的影响。
本研究旨在强调分类系统的变化对牙源性肿瘤患病率和相对频率的影响。次要目的是与已发表的文献相比，分析各种组织学类型牙源性肿瘤的人口统计学特征。最后总结了印度研究（1992 - 2020年）中关于牙源性肿瘤频率的阐述。
这是一项基于医院的回顾性研究，检索了1990年至2019年期间诊断为牙源性肿瘤的病例档案。保留诊断时最初使用的分类系统，并比较三个不同时期（1990 - 2004年、2005 - 2016年和2017 - 2019年）牙源性肿瘤的患病率。此外，使用世界卫生组织2017年最新分类分析所有这些肿瘤（1990 - 2019年）的患病率、频率分布和人口统计学特征。
根据世界卫生组织2017年分类系统，1990年至2019年共诊断出345例牙源性肿瘤。96.81%的肿瘤为良性，3.81%为恶性牙源性肿瘤。然而，与1990 - 2004年（3.87%）和2017 - 2019年（3.47%）相比，2005 - 2016年期间牙源性肿瘤的患病率显著增加（6.2%）。成釉细胞瘤在三个不同时期仍然是最常见的肿瘤，而与1990 - 2004年的牙瘤和2017 - 2019年的腺样牙源性肿瘤相比，角化囊性牙源性肿瘤在2005 - 2016年成为第二常见的肿瘤。
不断演变的分类系统可能部分导致牙源性肿瘤的不一致性，包括角化囊性牙源性肿瘤的纳入，并且对牙源性肿瘤的患病率和频率分布有显著影响。牙源性肿瘤人口统计学特征的地理差异可能反映了遗传和环境影响；然而，这需要进一步研究来阐明。
