Department of Family Medicine, Asan Medical Center, 88 Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Korea.
Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sci Rep. 2021 Mar 23;11(1):6605. doi: 10.1038/s41598-021-86186-2.
We aimed to examine whether metabolic syndrome (MetS) is associated with mobility in the older adults, using the timed up and go (TUG) test which is one of the most widely used tests for evaluating mobility. This is population-based study with the National Health Insurance Service-National Health Screening Cohort database of National Health Information Database. Participants included were those who completed the TUG as part of the National Screening Program for Transitional Ages. An abnormal TUG result was defined as a time ≥ 10 s. Multiple logistic regression models were used to assess the associations between MetS and TUG results. We constructed three models with different levels of adjustment. Furthermore, we conducted a stratified analysis according to the risk. Among the 40,767 participants included, 19,831 (48.6%) were women. Mean TUG value was 8.34 ± 3.07 s, and abnormal TUG test results were observed in 4,391 (10.8%) participants; 6,888 (16.9%) participants were categorised to have MetS. The worst TUG test results were obtained in participants with three or four MetS features, and a J-shaped relationship of each MetS feature, except triglyceride (TG) and high-density lipoprotein-cholesterol (HDL-C), with TUG test was found. Participants with MetS had 18% higher likelihood of showing abnormal TUG test results in a fully adjusted model (adjusted odds ratio 1.183, 95% confidence interval 1.115-1.254). The stratified analysis revealed that participants with central obesity, high blood pressure, and normal HDL-C and TG were more likely to have abnormal TUG times. Participants with MetS had a higher risk of exhibiting abnormal TUG results, and except for HDL-C and TG, all other MetS features had a J-shaped relationship with TUG. Preventive lifestyle such as lower carbohydrate and higher protein intake, and endurance exercise is needed.
我们旨在使用最常用于评估移动能力的测试之一——计时起立行走（TUG）测试，研究代谢综合征（MetS）与老年人的移动能力是否相关。这是一项基于人群的研究，使用了国家健康信息数据库的国民健康保险服务-国家健康筛查队列数据库。参与者包括完成全国过渡年龄段筛查计划中 TUG 测试的人群。异常 TUG 结果定义为时间≥10 秒。使用多因素逻辑回归模型评估 MetS 与 TUG 结果之间的关系。我们构建了三个具有不同调整水平的模型。此外，我们根据风险进行了分层分析。在纳入的 40767 名参与者中，有 19831 名（48.6%）为女性。平均 TUG 值为 8.34±3.07 秒，4391 名（10.8%）参与者的 TUG 测试结果异常；6888 名（16.9%）参与者被归类为患有 MetS。在具有三个或四个 MetS 特征的参与者中，TUG 测试结果最差，除甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）外，每个 MetS 特征都呈现出 J 形关系。在完全调整模型中，患有 MetS 的参与者发生异常 TUG 测试结果的可能性增加 18%（调整后的优势比 1.183，95%置信区间 1.115-1.254）。分层分析显示，患有中心性肥胖、高血压和正常 HDL-C 及 TG 的参与者更有可能出现异常 TUG 时间。患有 MetS 的参与者发生异常 TUG 结果的风险更高，除了 HDL-C 和 TG 之外，所有其他 MetS 特征与 TUG 都呈现 J 形关系。需要采取预防生活方式，如减少碳水化合物摄入、增加蛋白质摄入和耐力运动。
