体重与咖啡摄入量对健康青年男性血清瘦素、维生素B12和叶酸水平联合影响的横断面研究
A Cross-Sectional Study on the Combined Effect of Body Weight and Coffee Consumption on Serum Levels of Leptin, Vitamin B12, and Folic Acid in Healthy Young Adult Males.
作者信息
Hasoun Luai Z, Khader Heba A, Abu-Taha May Ibrahim, Mohammad Beisan A, Abu-Samak Mahmoud S
机构信息
Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan.
出版信息
J Multidiscip Healthc. 2021 Mar 15;14:639-650. doi: 10.2147/JMDH.S290990. eCollection 2021.
PURPOSE
Studies on the effect of body weight and coffee consumption on leptin, vitamin B12, and folic acid are scarce and conflicting. This study investigates the effect of body weight and/or coffee consumption rate on the serum levels of these molecules in healthy young adult males.
PATIENTS AND METHODS
This observational cross-sectional study was carried out at the faculty of pharmacy, Applied Science Private University (ASU), Amman, Jordan, from July to September 2020. Young healthy males were invited to participate in the study and fill a questionnaire regarding lifestyle habits including coffee consumption during the last 3 months, medical history, and anthropometric measurements. Depending on BMI and extent of coffee consumption, participants were divided into 4 groups; normal body weight and moderate coffee consumption (NW/MCC) group; normal body weight and heavy coffee consumption (NW/HCC) group; overweight and moderate coffee consumption (OW/MCC) group; overweight and heavy coffee consumption (OW/HCC) group. Serum samples were taken to measure leptin, vitamin B12, and folic acid levels in addition to morning and midnight salivary cortisol and dehydroepiandrosterone (DHEA) samples.
RESULTS
Healthy males (n = 122) aged 18 to 26 years continued participation in this study. Serum levels of leptin in NW/MCC, NW/HCC, OW/MCC, OW/HCC groups were 5.93, 5.75, 14.86, 16.79 ng/mL, respectively. Serum levels of vitamin B12 in these groups were 356.09, 402.71, 334.25, 331.05 pg/mL, respectively. While, the serum levels of folic acid were 8.92, 10.27, 10.12, 10.47 ng/mL, respectively. Body weight was positively associated with leptin (p = 0.00), negatively associated with vitamin B12 (p = 0.047), and not associated with folic acid (p = 0.235). Coffee consumption rate had no significant effect on leptin, vitamin B12, or folic acid. Finally, the combination of body weight and coffee consumption had no significant effect on leptin, vitamin B12, or folic acid.
CONCLUSION
There was no possible synergistic effect between body weight and coffee consumption rate on leptin, vitamin B12, or folic acid levels. However, overweight was associated with higher leptin, lower vitamin B12, and no change in folic acid levels.
TRIAL REGISTRATION
This trial was registered at clinicaltrials.gov as NCT04488731.
目的
关于体重和咖啡摄入量对瘦素、维生素B12和叶酸影响的研究较少且结果相互矛盾。本研究调查体重和/或咖啡饮用率对健康年轻成年男性这些分子血清水平的影响。
患者和方法
本观察性横断面研究于2020年7月至9月在约旦安曼应用科学私立大学药学院进行。邀请年轻健康男性参与研究并填写一份关于生活方式习惯的问卷，包括过去3个月的咖啡摄入量、病史和人体测量数据。根据体重指数（BMI）和咖啡摄入量，参与者被分为4组；正常体重和适度咖啡饮用（NW/MCC）组；正常体重和大量咖啡饮用（NW/HCC）组；超重和适度咖啡饮用（OW/MCC）组；超重和大量咖啡饮用（OW/HCC）组。采集血清样本以测量瘦素、维生素B12和叶酸水平，以及晨唾液和午夜唾液皮质醇和脱氢表雄酮（DHEA）样本。
结果
18至26岁的健康男性（n = 122）继续参与本研究。NW/MCC、NW/HCC、OW/MCC、OW/HCC组的血清瘦素水平分别为5.93、5.75、14.86、16.79 ng/mL。这些组的血清维生素B12水平分别为356.09、402.71、334.25、331.05 pg/mL。而血清叶酸水平分别为8.92、10.27、10.12、10.47 ng/mL。体重与瘦素呈正相关（p = 0.00），与维生素B12呈负相关（p = 0.047），与叶酸无相关性（p = 0.235）。咖啡饮用率对瘦素、维生素B12或叶酸无显著影响。最后，体重和咖啡饮用的组合对瘦素、维生素B12或叶酸无显著影响。
结论
体重和咖啡饮用率对瘦素、维生素B12或叶酸水平不存在协同效应。然而，超重与较高的瘦素水平、较低的维生素B12水平相关，且叶酸水平无变化。
试验注册
本试验在clinicaltrials.gov上注册，注册号为NCT04488731。
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