长链非编码RNA RP11-379k17.4衍生的微小RNA-200c-3p通过靶向Noxa调控人子宫内膜癌。
Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa.
作者信息
Xin Weijuan, Gao Xiaodong, Zhao Peng, Wang Taiyong, Ding Xue, Wu Qianyu, Hua Keqin
机构信息
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen-Yang Road, Shanghai 200090, China.
Department of Obstetrics and Gynecology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai 200120, China.
出版信息
J Cancer. 2021 Feb 22;12(8):2268-2274. doi: 10.7150/jca.51023. eCollection 2021.
The research paid close attention to the function of lncRNA-related endogenous competitive RNAs (ceRNAs) network in endometrial cancer (EC). 45 primary endometrial cancer tissues (EC) and 45 normal endometrium (NE) were included in the research. The online software StarbaseV2.0 was made use of forecasting the lncRNA which most likely contained microRNA-200c-3p combining sites and could interact with microRNA-200c-3p. Subsequently, we chose lncRNAs which were consistent with the characteristics of polyadenylation of lncRNAs and lower expression in EC than that of NE. After that, lncRNAs, which were related with the microRNA-200c-3p-noxa network, were identified. Rp11-379k17.4, a new gene related to endometrial cancer, was identified as noncoding RNA. It was a more effective ceRNA associated with the microRNA-200c-3p-noxa network. LncRNAs possess microRNA response elements (MREs) and give scope to significant roles in the post-transcriptional mechanism in EC.
该研究密切关注长链非编码RNA（lncRNA）相关的内源性竞争性RNA（ceRNA）网络在子宫内膜癌（EC）中的作用。该研究纳入了45例原发性子宫内膜癌组织（EC）和45例正常子宫内膜组织（NE）。利用在线软件StarbaseV2.0预测最有可能包含与微小RNA-200c-3p结合位点并能与微小RNA-200c-3p相互作用的lncRNA。随后，我们选择了符合lncRNA多聚腺苷酸化特征且在EC中表达低于NE的lncRNA。此后，鉴定了与微小RNA-200c-3p-noxa网络相关的lncRNA。Rp11-379k17.4，一种与子宫内膜癌相关的新基因，被鉴定为非编码RNA。它是一种与微小RNA-200c-3p-noxa网络相关的更有效的ceRNA。lncRNA具有微小RNA反应元件（MRE），并在EC的转录后机制中发挥重要作用。
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