Çetinkaya Feyza Nur, Koçak Fatmanur Aybala, Kurt Emine Eda, Güçlü Kenan, Tuncay Figen, Şaş Senem, Erdem Hatice Rana
Department of Physical Medicine and Rehabilitation, Kırşehir Ahi Evran University Faculty of Medicine, Kırşehir, Turkey.
Department of Medical Biochemistry, Kırşehir Ahi Evran University Training and Research Hospital, Kırşehir, Turkey.
Arch Rheumatol. 2020 Feb 7;35(4):506-514. doi: 10.46497/ArchRheumatol.2020.7857. eCollection 2020 Dec.
This study aims to evaluate whether there was a difference between oxidative stress index (OSI), total antioxidant status (TAS), and total oxidant status (TOS) values between patients with fibromyalgia syndrome (FMS) and healthy controls, and to show the effect of balneotherapy on clinical conditions such as pain, depression, and quality of life in patients with FMS and oxidative stress.
Thirty-five females (mean age 39.9±5.8 years; range, 18 to 50 years) with fibromyalgia and 35 healthy females (mean age 37.9±6.6 years; range, 18 to 50 years) were included in the study. The TAS, TOS, and OSI of patients with FMS and healthy controls were measured. Disease severity was evaluated using the Fibromyalgia Impact Questionnaire, pain levels were evaluated using a visual analog scale (VAS), mood was evaluated using the Beck Depression Inventory (BDI), and quality of life was evaluated using the Short Form 36 (SF-36). Patients with FMS were given 15 sessions of balneotherapy. After treatment, the laboratory and clinical parameters of the patients were reevaluated.
Although the TAS levels of patients with FMS were not significantly different from those of the control group (p=0.114), the TOS and OSI levels were higher than those of the control group (p<0.001). The VAS, BDI, and SF-36 parameter scores of patients with FMS were significantly higher than those of the control group (p<0.001). A statistically significant decrease (p<0.001) in TOS and OSI levels of patients with FMS was detected after balneotherapy; however, the TAS levels of patients with FMS did not change significantly (p=0.538). All clinical parameters showed significant improvement with balneotherapy (p<0.001).
An oxidative disorder was detected in patients with FMS compared with the control group. Balneotherapy showed antioxidant activity and decreased oxidative stress while also improving clinical parameters and quality of life.
本研究旨在评估纤维肌痛综合征（FMS）患者与健康对照者之间的氧化应激指数（OSI）、总抗氧化状态（TAS）和总氧化剂状态（TOS）值是否存在差异，并展示温泉疗法对FMS患者的疼痛、抑郁和生活质量等临床状况以及氧化应激的影响。
本研究纳入了35名患有纤维肌痛的女性（平均年龄39.9±5.8岁；范围18至50岁）和35名健康女性（平均年龄37.9±6.6岁；范围18至50岁）。测量了FMS患者和健康对照者的TAS、TOS和OSI。使用纤维肌痛影响问卷评估疾病严重程度，使用视觉模拟量表（VAS）评估疼痛程度，使用贝克抑郁量表（BDI）评估情绪，使用简短健康调查问卷（SF - 36）评估生活质量。给予FMS患者15次温泉疗法治疗。治疗后，重新评估患者的实验室和临床参数。
虽然FMS患者的TAS水平与对照组无显著差异（p = 0.114），但TOS和OSI水平高于对照组（p < 0.001）。FMS患者的VAS、BDI和SF - 36参数得分显著高于对照组（p < 0.001）。温泉疗法后检测到FMS患者的TOS和OSI水平有统计学意义的下降（p < 0.001）；然而，FMS患者的TAS水平无显著变化（p = 0.538）。所有临床参数在温泉疗法后均有显著改善（p < 0.001）。
与对照组相比，FMS患者存在氧化紊乱。温泉疗法显示出抗氧化活性，降低了氧化应激，同时还改善了临床参数和生活质量。
