The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Marburg Building Room 113, Baltimore, MD, 21287, USA.
Cellular and Molecular Medicine Program, Johns Hopkins School of Medicine, 1830 E. Monument St., Baltimore, MD, 21205, USA.
Med Oncol. 2021 Mar 24;38(5):47. doi: 10.1007/s12032-021-01494-x.
Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well.
驱动蛋白在癌症的进展和发展中发挥着重要作用。驱动蛋白家族成员 C1（KIFC1）是一种负向末端导向的马达蛋白，是一种新型的驱动蛋白，参与了癌细胞中过多中心体的聚集。最近，KIFC1 已被证明在多种不同癌症的进展中发挥作用，然而，KIFC1 参与前列腺癌（PCa）的进展仍未得到很好的理解。本研究通过利用多个公开可用的数据集来分析患者样本中的 KIFC1 表达，探讨了 KIFC1 在 PCa 中的表达和临床意义。研究发现，高 KIFC1 表达与高 Gleason 评分、高肿瘤分期、转移性病变、高倍性水平和较低的无复发生存率相关。这些结果表明，高水平的 KIFC1 与 PCa 患者的预后不良相关，并且可以作为 PCa 患者的预后指标。
