Wu Hao, Duan Yingjuan, Gong Siming, Zhu Qiang, Liu Xuanyou, Liu Zhenguo
Center for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Faculty of Chemistry and Mineralogy, University of Leipzig, 04103 Leipzig, Germany.
Biomedicines. 2022 Mar 10;10(3):637. doi: 10.3390/biomedicines10030637.
Kinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary centrosomes, and it is associated with the initiation and progression of cancers. In the present study, we initially reviewed the The Cancer Genome Atlas database and observed that is abundantly expressed in most types of tumors. We then analyzed the gene alteration profiles, protein expressions, prognoses, and immune reactivities of KIFC1 in more than 10,000 samples from several well-established databases. In addition, we conducted a gene set enrichment analysis to investigate the potential mechanisms for the roles of in carcinogenesis. The pan-cancer analysis of KIFC1 demonstrates significant statistical correlations of the KIFC1 expression with the clinical prognoses, the oncogenic signature gene sets, the myeloid-derived suppressor cell infiltration, the ImmunoScore, the immune checkpoints, the microsatellite instabilities, and the tumor mutational burdens across multiple tumors. These data may provide important information on the understanding of the role and mechanisms of KIFC1 in carcinogenesis and immunotherapy, as well as on the clinical progression of a variety of cancers.
驱动蛋白家族成员C1（KIFC1）是一种向微管负端移动的驱动蛋白，在微管交联和纺锤体形成中起关键作用。KIFC1对于多余中心体至关重要，并且与癌症的发生和发展相关。在本研究中，我们首先查阅了癌症基因组图谱数据库，发现其在大多数肿瘤类型中均有大量表达。然后，我们分析了来自几个成熟数据库的一万多个样本中KIFC1的基因改变图谱、蛋白表达、预后及免疫反应性。此外，我们进行了基因集富集分析，以探究其在致癌作用中的潜在机制。KIFC1的泛癌分析表明，KIFC1表达与多种肿瘤的临床预后、致癌特征基因集、髓源性抑制细胞浸润、免疫评分、免疫检查点、微卫星不稳定性及肿瘤突变负荷之间存在显著的统计学相关性。这些数据可能为理解KIFC1在致癌作用和免疫治疗中的作用及机制，以及各种癌症的临床进展提供重要信息。
