Laboratory for Polymer Analysis, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram, 695012, India.
Department of Chemistry NSS college, Kollam, Nilamel, 691536, India.
J Fluoresc. 2021 May;31(3):847-852. doi: 10.1007/s10895-021-02712-5. Epub 2021 Mar 24.
The varied applications of nanotechnology have paved way for several breakthroughs in the realm of biomedical technology. In this challenging era when illness multiplies, timely and accurate disease diagnosis is very important. Thus, well founded novel approaches matter very much in areas like disease diagnosis and monitoring. Nanomedicine has tremendous implications in the given context. An elevated cholesterol concentration in blood is risky and is associated with cardiovascular diseases (CVD). CVD remains the No. 1 global cause of death and hence there is an urge to understand cholesterol level and take preventive measures. Highly fluorescent graphene quantum dots (GQs) are well known for their biocompatibility, non toxicity and aqueous solubility. Here in we report an easy and sensitive non enzymatic based cholesterol detection using digitonin conjugated graphene quantum dots (GDG). Selectivity studies and the cholesterol detection in human blood serum suggests the probe to be reliable and selective for blood cholesterol monitoring. Digitonin conjugated fluorescent graphene quantumdots, an efficient probe for cholesterol sensing.
纳米技术的各种应用为生物医学技术领域的多项突破铺平了道路。在这个疾病不断增多的挑战时代，及时、准确的疾病诊断非常重要。因此，在疾病诊断和监测等领域，有充分依据的新方法非常重要。在这种情况下，纳米医学具有巨大的意义。血液中胆固醇浓度升高是有风险的，并且与心血管疾病 (CVD) 有关。CVD 仍然是全球头号死因，因此迫切需要了解胆固醇水平并采取预防措施。高荧光石墨烯量子点 (GQ) 以其生物相容性、非毒性和水溶性而闻名。在这里，我们报告了一种使用皂素共轭石墨烯量子点 (GDG) 的简单、灵敏的非酶基胆固醇检测方法。选择性研究和人血清中的胆固醇检测表明，该探针可用于可靠、选择性地监测血液胆固醇。皂素共轭荧光石墨烯量子点是一种用于胆固醇传感的高效探针。
