Krinke G J, Fitzgerald R E
Ciba-Geigy AG, Basel, Switzerland.
Toxicology. 1988 Apr;49(1):171-8. doi: 10.1016/0300-483x(88)90190-4.
A fundamental prerequisite for the design of neurotoxicological safety studies is the determination of the target areas in the nervous system which are specific for particular kinds of toxicants. The target areas should be identified in special "lesion-pattern-finding" experiments. The pyridoxine-induced lesion is a prototype of the pattern characteristic of a peripheral, primary sensory neuropathy. Depending on the conditions of treatment such as the dosage level and the timing of examination, the structural changes may be more obvious either in the proximal or the distal portion of the neuron, while the functional signs may vary from severe sensory paralysis to quite unremarkable behavior.
神经毒理学安全性研究设计的一个基本前提是确定神经系统中对特定类型毒物具有特异性的靶区域。应在特殊的“损伤模式发现”实验中识别靶区域。吡哆醇诱导的损伤是周围性原发性感觉神经病变特征模式的一个原型。根据治疗条件，如剂量水平和检查时间，神经元近端或远端的结构变化可能更明显，而功能体征可能从严重的感觉麻痹到相当不明显的行为有所不同。
