Prince Sattam bin Abdulaziz University.
Cairo University.
Pediatr Exerc Sci. 2021 Mar 22;33(1):23-31. doi: 10.1123/pes.2020-0076.
To appraise the effects of incremental aerobic training (IAT) on systemic inflammatory mediators, cardiorespiratory indices, and functional capacity in obese children with bronchial asthma.
This study included 30 children with asthma (age = 8-16 y) allocated randomly into either the control group (n = 15; received the traditional pulmonary rehabilitation program) or IAT group (n = 15; engaged in 8 weeks of IAT in addition to the traditional pulmonary rehabilitation program). The systemic inflammatory mediators (high-sensitivity C-reactive protein and interleukin-6), cardiorespiratory indices (peak oxygen uptake, minute ventilation, maximum heart rate, heart rate recovery at 1 min after exercises, and oxygen pulse), and functional capacity (represented by 6-min walk test) were analyzed pretreatment and posttreatment.
A significant reduction in the level of high-sensitivity C-reactive protein and interleukin-6 and increase in peak oxygen uptake, minute ventilation, maximum heart rate, and heart rate recovery at 1 minute after exercises was observed among the IAT group as compared with the control group. In addition, the IAT group covered a longer distance in the 6-minute walk test than the control group, suggesting favorable functional capacity.
The study results imply that IAT has the potential to improve the inflammatory profile, cardiorespiratory fitness, and functional capacity of obese children with bronchial asthma.
评估递增有氧运动（IAT）对支气管哮喘肥胖儿童全身炎症介质、心肺指标和功能能力的影响。
本研究纳入 30 名哮喘患儿（年龄 8-16 岁），随机分为对照组（n=15；接受传统肺康复计划）或 IAT 组（n=15；在传统肺康复计划的基础上进行 8 周 IAT）。分析治疗前后全身炎症介质（高敏 C 反应蛋白和白细胞介素 6）、心肺指标（峰值摄氧量、分钟通气量、最大心率、运动后 1 分钟心率恢复和氧脉搏）和功能能力（以 6 分钟步行试验表示）。
与对照组相比，IAT 组的高敏 C 反应蛋白和白细胞介素 6 水平显著降低，峰值摄氧量、分钟通气量、最大心率和运动后 1 分钟心率恢复均增加。此外，IAT 组在 6 分钟步行试验中走的距离比对照组更长，表明功能能力有所改善。
研究结果表明，IAT 有可能改善支气管哮喘肥胖儿童的炎症谱、心肺功能和功能能力。
