膜细胞质易位的膜联蛋白 A4 参与结直肠癌的转移。
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
机构信息
Hunan Provincial People's Hospital and the Affiliated Hunan Normal University, Changsha 410081, Hunan, China.
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410008, Hunan, China.
出版信息
Aging (Albany NY). 2021 Mar 24;13(7):10312-10325. doi: 10.18632/aging.202793.
Annexin A4 (ANXA4) is a Ca- and phospholipid-binding protein that belongs to the annexin family, which is involved in the development of multiple tumour types via NF-κB signalling. In this study, we verified the high expression and membrane-cytoplasm translocation of ANXA4 in colorectal carcinoma (CRC). Calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) was found to be important for high ANXA4 expression in CRC, whereas carbonic anhydrase (CA1) promoted ANXA4 aggregation in the cell membrane. An increased Ca concentration attenuated the small ubiquitin-like modifier (SUMO) modification of cytoplasmic ANXA4 and ANXA4 stabilization, and relatively high expression of ANXA4 promoted CRC tumorigenesis and epithelial-mesenchymal transition (EMT).
膜联蛋白 A4（ANXA4）是一种钙和磷脂结合蛋白，属于膜联蛋白家族，通过 NF-κB 信号通路参与多种肿瘤类型的发展。在这项研究中，我们验证了结直肠癌（CRC）中 ANXA4 的高表达和质膜易位。钙/钙调蛋白依赖性蛋白激酶 II 伽马（CAMK2γ）被发现对 CRC 中高表达的 ANXA4 很重要，而碳酸酐酶（CA1）促进 ANXA4 在细胞膜上聚集。钙离子浓度增加减弱了细胞质 ANXA4 的小泛素样修饰（SUMO）修饰和 ANXA4 的稳定，相对高表达的 ANXA4 促进 CRC 肿瘤发生和上皮-间充质转化（EMT）。
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