2 型糖尿病患者的血糖变异性与心血管疾病。
Glycemic variability and cardiovascular disease in patients with type 2 diabetes.
机构信息
Diabetes and Metabolism, Favaloro Foundation University Hospital, Buenos Aires, Federal District, Argentina.
Diabetes and Endocrinology, Favaloro Foundation University Hospital, Buenos Aires, Federal District, Argentina.
出版信息
BMJ Open Diabetes Res Care. 2021 Mar;9(1). doi: 10.1136/bmjdrc-2020-002032.
Abstract
Glycated hemoglobin is currently the gold standard for assessment of long-term glycemic control and response to medical treatment in patients with diabetes. Glycated hemoglobin, however, does not address fluctuations in blood glucose. Glycemic variability (GV) refers to fluctuations in blood glucose levels. Recent clinical data indicate that GV is associated with increased risk of hypoglycemia, microvascular and macrovascular complications, and mortality in patients with diabetes, independently of glycated hemoglobin level. The use of continuous glucose monitoring devices has markedly improved the assessment of GV in clinical practice and facilitated the assessment of GV as well as hypoglycemia and hyperglycemia events in patients with diabetes. We review current concepts on the definition and assessment of GV and its association with cardiovascular complications in patients with type 2 diabetes.
摘要
糖化血红蛋白目前是评估糖尿病患者长期血糖控制和治疗反应的金标准。然而，糖化血红蛋白并不能解决血糖波动的问题。血糖变异性（GV）是指血糖水平的波动。最近的临床数据表明，GV 与糖尿病患者低血糖、微血管和大血管并发症以及死亡率的增加相关，独立于糖化血红蛋白水平。连续血糖监测设备的使用显著改善了 GV 在临床实践中的评估，并促进了对 GV 以及糖尿病患者低血糖和高血糖事件的评估。我们回顾了关于 GV 的定义和评估及其与 2 型糖尿病患者心血管并发症之间关联的当前概念。
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