Department of Pulmonary Medicine, University Hospital Essen-Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Essen, Germany.
Pediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Center, Children's Hospital, University of Duisburg-Essen, Essen, Germany.
Pulm Med. 2021 Mar 9;2021:5581812. doi: 10.1155/2021/5581812. eCollection 2021.
Regular physical activity plays an important role in the treatment of patients with cystic fibrosis (CF). This study is aimed at investigating the effects of a 12-month partially supervised exercise program on attributes of health-related and motor performance fitness, lung function (ppFEV1), BMI, and habitual physical activity (HPA, steps/day) in adults with CF.
Attributes of health-related and motor performance fitness were examined at the beginning (T0), after 6 (T1), and 12 months (T2) on the basis of five test items: forward bend (FB), bent knee hip extension (HE), plank leg raise (PLR), standing long jump (SLJ), and standing on one leg (OLS). Additionally, we recorded HPA by accelerometry, peak exercise performance ( ) by an incremental cycle test, ppFEV1, and BMI. During the first six months, there was close supervision by an experienced sport therapist.
26 CF patients (8 female, mean age 26.5 ± 7.9 years; ppFEV1 53.7 ± 21.0) completed the exercise program. Significant improvements were recorded from T0 to T1 (FB: ≤ 0.05; PLR, OLS: ≤ 0.01) and from T0 to T2 (FB, PLR: ≤ 0.01 and HE, OLS: ≤ 0.05). , ppFEV1, BMI, and HPA showed no significant improvement between the single test points and over the entire study period (all > 0.05).
Our results show trainability of adults with CF in aspects of health-related and motor performance fitness during a partially supervised exercise program. Close supervision positively influences the results. Using a simple test setup seems to be a promising tool for evaluating the effects of exercise programs in CF and could serve as an additional outcome parameter in future clinical trials. Trial registration: ClinicalTrials.gov (retrospectively registered May 8, 2018).
定期进行身体活动对囊性纤维化（CF）患者的治疗起着重要作用。本研究旨在调查为期 12 个月的部分监督运动方案对 CF 成人健康相关和运动表现适应性、肺功能（ppFEV1）、体重指数（BMI）和习惯性体力活动（HPA，步数/天）的影响。
根据五项测试项目（前屈、屈膝髋关节伸展、平板支撑腿抬高、立定跳远和单腿站立），在开始时（T0）、6 个月后（T1）和 12 个月后（T2）检查健康相关和运动表现适应性的特征。此外，我们通过加速度计记录 HPA，通过递增式自行车测试记录峰值运动表现（ ），ppFEV1 和 BMI。在前六个月，由一位经验丰富的运动治疗师进行密切监督。
26 名 CF 患者（8 名女性，平均年龄 26.5 ± 7.9 岁；ppFEV1 53.7 ± 21.0）完成了运动方案。从 T0 到 T1（前屈： ≤ 0.05；平板支撑腿抬高、单腿站立： ≤ 0.01）和从 T0 到 T2（前屈、平板支撑腿抬高： ≤ 0.01 和屈膝髋关节伸展、单腿站立： ≤ 0.05）均记录到显著改善。 、ppFEV1、BMI 和 HPA 在各单项测试点和整个研究期间均未显示出显著改善（均 ＞ 0.05）。
我们的结果表明，在部分监督运动方案中，CF 成人在健康相关和运动表现适应性方面具有可训练性。密切监督对结果有积极影响。使用简单的测试设置似乎是评估 CF 运动方案效果的有前途的工具，并可作为未来临床试验的附加结果参数。
ClinicalTrials.gov（于 2018 年 5 月 8 日回溯性注册）。
