血清 S100A11 和 MMP-9 水平在卵巢上皮性癌患者中的变化及其临床意义。
Serum Levels of S100A11 and MMP-9 in Patients with Epithelial Ovarian Cancer and Their Clinical Significance.
机构信息
Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
出版信息
Biomed Res Int. 2021 Mar 3;2021:7341247. doi: 10.1155/2021/7341247. eCollection 2021.
OBJECTIVE
To investigate the serum levels of calgizzarin (S100A11) and matrix metalloproteinase-9 (MMP9) in patients with epithelial ovarian cancer (EOC) and determine their clinical significance.
METHODS
Serum levels of S100A11 and MMP9 were detected in patients with EOC, patients with benign ovarian tumor, and healthy women. The correlation between the two markers and clinicopathological characteristics of ovarian cancer was analysed.
RESULTS
The serum levels of S100A11 and MMP-9 in patients with EOC were higher than those in patients with benign ovarian tumor and in healthy women, and the expression levels of S100A11 and MMP-9 were positively correlated. S100A11 and MMP-9 were correlated with tumor staging, postoperative residual foci, ascites volume, serum CA125 level, chemotherapy response, and lymph node metastasis, while S100A11 and MMP-9 were not associated with the bilevel classification, histological type, age, and degree of differentiation.
CONCLUSION
S100A11 and MMP-9 were both highly expressed in the serum of patients with EOC and were associated with cancer development, invasion, and metastasis. Therefore, they can be used as an important reference maker in the diagnosis and treatment of ovarian cancer.
目的
探讨钙粒蛋白（S100A11）和基质金属蛋白酶-9（MMP9）在卵巢上皮癌（EOC）患者中的血清水平及其临床意义。
方法
检测 EOC 患者、良性卵巢肿瘤患者和健康女性的 S100A11 和 MMP9 血清水平，分析两种标志物与卵巢癌临床病理特征的相关性。
结果
EOC 患者的 S100A11 和 MMP-9 血清水平高于良性卵巢肿瘤患者和健康女性，且 S100A11 和 MMP-9 的表达水平呈正相关。S100A11 和 MMP-9 与肿瘤分期、术后残留病灶、腹水体积、血清 CA125 水平、化疗反应和淋巴结转移相关，而与双相分类、组织学类型、年龄和分化程度无关。
结论
S100A11 和 MMP-9 在 EOC 患者的血清中均呈高表达，与癌症的发生、侵袭和转移有关。因此，它们可以作为卵巢癌诊断和治疗的重要参考标志物。
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