Gåfvels M, Norjavaara E, Selstam G
Department of Physiology, University of Umeå, Sweden.
Ups J Med Sci. 1988;93(1):19-32. doi: 10.1517/03009734000000033.
The effect of a 20 min continuous infusion of noradrenaline (2 nanomoles/min) on the blood flow and vascular resistance of 2-, 6- and 11-day-old corpora lutea from adult pseudopregnant rats was studied. Pseudopregnancy was induced by mating with vasectomized male rats. The blood flow of the corpus luteum and the remaining ovary was measured with the microsphere technique. The basal blood flow varied between the luteal ages studied and was highest at day 6 of pseudopregnancy. Noradrenaline induced a two-fold increase in the blood flow of the corpus luteum at the luteal ages studied. The vascular resistance (blood pressure/blood flow) decreased for all luteal ages, while the vascular resistance for kidney, spleen and diaphragm was unchanged. Antidiuretic hormone was found to markedly decrease the luteal blood flow and the vascular resistance remained increased. The effect of noradrenaline infusion on the luteal blood flow thus in contrast to other vasoactive substances is biphasic, with an initial vasoconstriction followed by vasodilatation.
研究了连续20分钟输注去甲肾上腺素（2纳摩尔/分钟）对成年假孕大鼠2日龄、6日龄和11日龄黄体的血流及血管阻力的影响。假孕通过与输精管结扎的雄性大鼠交配诱导产生。用微球技术测量黄体和剩余卵巢的血流。在所研究的黄体期之间，基础血流有所不同，在假孕第6天最高。在所研究的黄体期，去甲肾上腺素使黄体血流增加了两倍。所有黄体期的血管阻力（血压/血流）均降低，而肾脏、脾脏和膈肌的血管阻力未变。发现抗利尿激素可显著降低黄体血流，且血管阻力仍增加。因此，与其他血管活性物质相比，输注去甲肾上腺素对黄体血流的影响是双相的，最初是血管收缩，随后是血管舒张。
