Ghafouri-Fard Soudeh, Honarmand Tamizkar Kasra, Sayad Arezou, Taheri Mohammad, Samadian Mohammad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Mol Neurosci. 2021 Sep 27;14:725048. doi: 10.3389/fnmol.2021.725048. eCollection 2021.
Migraine is a complex neurological condition affecting a large proportion of persons. Dysregulation of several immune-related transcripts has been noted in migraineurs suggesting an immune-based background for this condition. We measured expression levels () genes in the venous blood of migraineurs compared with controls. was down-regulated in patients without aura compared with controls [Ratio of mean expression (RME) = 0.08, value < 0.001]. This pattern was also detected among female subgroups (RME = 0.06, value = 0.010), but not among male subgroups (RME = 0.22, value = 0.114). Expression of was significantly higher in patients with aura compared with those without aura (RME = 5.89, value = 0.037). Meanwhile, expression of was lower in migraineurs with aura compared with controls (RME = 0.03, value < 0.001). In addition, this gene was under-expressed in patients without aura compared with controls and in both sex-based subgroups of this group of patients (RME = 0.01, value < 0.001 for all comparisons). However, its expression was higher in male patients with aura compared with those without aura ( value < 0.001). For , we detected a lower level of expression in patients without aura compared with controls (RME = 0.07, value < 0.001). However, the expression of was higher in patients with aura compared with those without aura (RME = 7.46, value = 0.001). was down-regulated in patients without aura compared with controls (RME = 0.10, value < 0.001). Expression of this gene was also lower in patients with aura compared with controls (RME = 0.03, value < 0.001), and in male patients of this group compared with controls (RME = 0.03, value = 0.004). On the other hand, expression of was higher in male patients with aura compared with sex-matched patients without aura (RME = 6.67, value = 0.001). levels could appropriately differentiate migraineurs from healthy subjects. The current study suggests the role of genes in the pathoetiology of migraine.
偏头痛是一种影响很大一部分人的复杂神经系统疾病。偏头痛患者中已注意到几种免疫相关转录本的失调，这表明该疾病存在基于免疫的背景。我们测量了偏头痛患者与对照组静脉血中（）基因的表达水平。与对照组相比，无先兆患者中的该基因下调[平均表达比值（RME）=0.08，值<0.001]。在女性亚组中也检测到这种模式（RME=0.06，值=0.010），但在男性亚组中未检测到（RME=0.22，值=0.114）。与无先兆患者相比，有先兆患者中的表达显著更高（RME=5.89，值=0.037）。同时，与对照组相比，有先兆偏头痛患者中的表达较低（RME=0.03，值<0.001）。此外，与对照组相比，无先兆患者以及该组患者的两个性别亚组中该基因表达不足（所有比较的RME=0.01，值<0.001）。然而，与无先兆男性患者相比，有先兆男性患者中的表达更高（值<0.001）。对于，与对照组相比，我们在无先兆患者中检测到较低的表达水平（RME=0.07，值<0.001）。然而，与无先兆患者相比，有先兆患者中的表达更高（RME=7.46），值=0.001）。与对照组相比，无先兆患者中的该基因下调（RME=0.10，值<0.001）。与对照组相比，该组有先兆患者中的该基因表达也较低（RME=0.03，值<0.001），并且与对照组相比，该组男性患者中的表达较低（RME=0.03，值=0.004）。另一方面，与无先兆的性别匹配患者相比，有先兆男性患者中的表达更高（RME=6.67，值=0.001）。水平可以适当地将偏头痛患者与健康受试者区分开来。当前研究表明基因在偏头痛发病机制中的作用。
