German Cancer Research Center (DKFZ), Heidelberg, Germany.
EMBO J. 2021 Apr 15;40(8):e108070. doi: 10.15252/embj.2021108070. Epub 2021 Mar 25.
Glycosphingolipids are a structurally diverse class of lipids that regulate plasma membrane protein function. Rizzo et al (2021) now show that GOLPH3 promotes intra-Golgi transport of several enzymes that function at branching points of sphingolipid biosynthesis. By regulating the cellular sphingolipidome, GOLPH3 promotes growth factor signaling and cell proliferation, which may explain its oncogenic properties.
糖脂是一类结构多样的脂质，可调节质膜蛋白的功能。Rizzo 等人（2021 年）现在表明，GOLPH3 促进了几种在鞘脂生物合成分支点起作用的酶在高尔基体内的运输。通过调节细胞内鞘脂组，GOLPH3 促进了生长因子信号和细胞增殖，这可能解释了其致癌特性。
