Research Group Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp (UA), Antwerp, Belgium.
Department of Dermatology, University Hospital Antwerp (UZA), Edegem, Belgium.
Contact Dermatitis. 2021 Jul;85(1):69-77. doi: 10.1111/cod.13845. Epub 2021 Apr 13.
The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic ultraviolet filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen.
To verify if, and to what extent, BP residues are present in OCT-containing consumer products.
The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chemically analysed for the presence of BP by means of liquid chromatography.
In the OCT raw material and in all 28 OCT-containing products the presence of BP could be demonstrated, mostly in concentrations above 10 ppm (0.001%), whereas a majority of OCT-free products (8/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time- and temperature-dependent manner, likely due to the additional degradation of OCT.
Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicological and ecological studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP.
为何对药物酮洛芬（KP）过敏的患者会对防晒霜和化妆品中含有的有机紫外线滤光剂奥克立林（OCT）产生严重的光过敏皮肤反应，其原因在很大程度上尚不清楚。OCT 可通过使用未取代的二苯甲酮（BP）来合成，BP 可能是一种人类致癌物质。
验证 OCT 含有的消费产品中是否存在 BP 及其存在程度。
采用液相色谱法对 OCT 原料和 39 种护肤品（其中 28 种含有 OCT）进行化学分析，以确定 BP 的存在。
在 OCT 原料和所有 28 种含有 OCT 的产品中均能检测到 BP 的存在，其浓度大多超过 10ppm（0.001%），而大多数不含 OCT 的产品（11 种中的 8 种，73%）则不含 BP。此外，BP 浓度会随时间和温度的增加而显著增加，可能是由于 OCT 的额外降解所致。
对 KP 过敏的患者对 OCT 产生光过敏接触性皮炎，可能依赖于残留的 BP 杂质。评估 OCT 安全性的毒理学和生态研究可能还需要考虑 BP 的同时存在。
