Faculty of Medicine, Department of Radiology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
Laryngoscope. 2022 Jan;132(1):188-197. doi: 10.1002/lary.29532. Epub 2021 Mar 25.
To determine the cochlea's average size in humans and evaluate the relationships between certain covariates and cochlear size.
A systematic search on articles on cochlear size and published in English was conducted using Cochrane, PubMed, Web of Science, and Scopus databases up to September 15, 2020. Data were pooled using random-effects with three models. The effect of demographic, clinical, and measurement-related parameters was specifically analyzed. Meta-regression and subgroup analyses were conducted. The overall effect estimation was made for outcomes.
The meta-analysis included 4,708 cochleae from 56 studies. The overall length of the organ of Corti was 32.94 mm (95% confidence interval [CI]: 32.51-33.38). The first and second models revealed that age, gender, country, continent, measurement method (direct, indirect), measured structure ("A" value, cochlear lateral wall), origin (in vivo, in vitro), and type (histology specimens, plastic casts, imaging) of the cochlear material did not affect the cochlear size. However, study populations (general population, patients with a cochlear implant, and patients with congenital sensorineural hearing loss [CSNHL]) were found to affect the outcomes. Compared to the other populations, patients with CSNHL had shorter cochleae. Therefore, we developed a third model and found that the general population and patients with cochlear implants did not differ in cochlear size.
This meta-analysis investigated the factors that could affect the cochlear size and found that patients with CSNHL had significantly shorter cochleae, whereas other covariates had no significant effect. Laryngoscope, 132:188-197, 2022.
确定人类耳蜗的平均大小，并评估某些协变量与耳蜗大小之间的关系。
系统检索了截至 2020 年 9 月 15 日在 Cochrane、PubMed、Web of Science 和 Scopus 数据库中以英文发表的关于耳蜗大小的文章，使用随机效应模型进行了数据汇总。特别分析了人口统计学、临床和测量相关参数的影响。进行了元回归和亚组分析。对结果进行了总体效应估计。
荟萃分析包括 56 项研究的 4708 个耳蜗。耳蜗的外毛细胞总长为 32.94mm（95%置信区间[CI]：32.51-33.38）。第一和第二模型表明，年龄、性别、国家、大陆、测量方法（直接、间接）、测量结构（“A”值、耳蜗外侧壁）、来源（体内、体外）和耳蜗材料的类型（组织学标本、塑料铸型、成像）对耳蜗大小没有影响。然而，研究人群（一般人群、耳蜗植入患者和先天性感觉神经性听力损失[CSNHL]患者）被发现会影响结果。与其他人群相比，CSNHL 患者的耳蜗较短。因此，我们建立了第三个模型，发现一般人群和耳蜗植入患者的耳蜗大小没有差异。
本荟萃分析研究了可能影响耳蜗大小的因素，发现 CSNHL 患者的耳蜗明显较短，而其他协变量对耳蜗大小没有显著影响。《喉镜》，132：188-197，2022。
